- From: Kathrin Dentler <k.dentler@vu.nl>
- Date: Fri, 26 Jul 2013 09:34:07 +0200
- To: Andrea Splendiani <andrea.splendiani@iscb.org>
- CC: <public-semweb-lifesci@w3.org>
Hi Andrea, I'm also sorry for the late reply. My colleagues have been working on a library of eligibility criteria to support the design of clinical trials [1]. The criteria are now online in a triple store and visualised / searchable [2]. Also, an article [3] has been published lately that analyses eligibility criteria representation in industry-standard clinical trial protocols, and the authors state that the criteria from clinicaltrials.gov (used in most studies) differ from criteria in original full-text criteria. I hope it helps! Best, Kathrin [1] http://www.cs.vu.nl/~frankh/postscript/EKAW2012.pdf [2] http://semweb.cs.vu.nl/eligibility [3] http://www.sciencedirect.com/science/article/pii/S1532046413000762 Op 7/22/13 11:09 PM, Andrea Splendiani schreef: > HI, > > thanks and sorry for the late reply. I have been doing a bit of reading. > Let's say I am up2date until more or less the date of your review (2007). > > First, I wonder if something new come out since then (rather than evolutions of approaches/standards already existing). > > Second, I got the impression that rationales to standardize clinical trials criteria vary a lot. Mining EHRs for candidates has different requirements from criteria re-use, which in turns has different requirements from (trials) discovery. > I was looking for some sampling of criteria in use in clinical trials. Could not find anything (at least open). Does anybody have some pointer in this direction ? > > > best, > Andrea > > > > Il giorno 15/lug/2013, alle ore 07:21, Kathrin Dentler <k.dentler@vu.nl> ha scritto: > >> Hi Andrea, >> >> For a first broad overview, this paper is a good starting point: >> Formal representation of eligibility criteria: A literature review >> http://www.sciencedirect.com/science/article/pii/S1532046409001592 >> >> For CDISC, there is ongoing work on OWL/RDF formats: >> http://www.cancer.gov/cancertopics/cancerlibrary/terminologyresources/cdisc >> http://kerfors.blogspot.nl/2012/05/semantic-models-for-cdisc-based.html >> >> Best, >> Kathrin >> >> >> >> Op 7/15/13 1:34 AM, Andrea Splendiani schreef: >>> Hi, >>> >>> I was wondering if somebody could provide some pointer to work going on in an area that is related to clinical trials: inclusion and exclusion criteria. >>> (I have followed the recent thread on encoding Hamilton Disease and pointers). >>> >>> In, particular, I am interested in two things: >>> Standards with substantial uptake (sub question: is CDISC's uptake actual or perspective ?). >>> >>> Modeling of inclusion/exclusion criteria, but with a particular twist: not modeling the questions, but the facts that are queried. Basically I am interested in modeling patients and conditions (to the level of detail required "usually" required by clinical trials). The subject itself can be very vast, but is there a framework which provides at least an upper perspective on how to model subjects's features, diseases, interventions, samples (also respect to time) ? >>> >>> Any pointer is welcome! >>> >>> best, >>> Andrea Splendiani >>> >>> >> >> -- >> Kathrin Dentler >> >> AI Department | Department of Medical Informatics >> Faculty of Sciences | Academic Medical Center >> Vrije Universiteit | Universiteit van Amsterdam >> k.dentler@vu.nl | k.dentler@amc.uva.nl >> >> http://www.few.vu.nl/~kdr250/ >> >> -- Kathrin Dentler AI Department | Department of Medical Informatics Faculty of Sciences | Academic Medical Center Vrije Universiteit | Universiteit van Amsterdam k.dentler@vu.nl | k.dentler@amc.uva.nl http://www.few.vu.nl/~kdr250/
Received on Friday, 26 July 2013 07:34:32 UTC