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RE: Encoding the Hamilton Depression Rating Scale….

From: Lin MD, Simon <LINMD.SIMON@mcrf.mfldclin.edu>
Date: Fri, 12 Jul 2013 18:39:44 +0000
To: Kerstin Forsberg <kerstin.l.forsberg@gmail.com>, "Luciano, Joanne S." <luciaj2@rpi.edu>
CC: public-semweb-lifesci hcls <public-semweb-lifesci@w3.org>, Brendan Ashby <morrowind789@gmail.com>
Message-ID: <A5BD550FC766564987DA2A5977989030507B2442@MCL-EXMB04.mfldclin.org>
I am very much interested in this conversation.

The Marshfield team is looking into using a smartphone platform for patients to collect patient-reported outcomes (PRO) for clinical use. Our use cases are for cancer and neurology patients. Your inputs are welcome!

The ontology will make the data collection integratable.


Simon Lin, MD | Director, Biomedical Informatics Research Center | Marshfield Clinic Research Foundation | 1000 N Oak Ave, Marshfield, WI 54449 | 715-221-7299 | Lin.Simon@mcrf.mfldclin.edu | www.marshfieldclinic.org/birc

From: Kerstin Forsberg [mailto:kerstin.l.forsberg@gmail.com]
Sent: Friday, July 12, 2013 11:30 AM
To: Luciano, Joanne S.
Cc: public-semweb-lifesci hcls; Brendan Ashby
Subject: Re: Encoding the Hamilton Depression Rating Scale….

See also DDI for "data from the social, behavioral, and economic sciences."

We had a short call with the folks behind it (and the related
RDF Data Cube) in reviewing the CDISC2RDF schema.

It would be great to see the different options applied as RDF
side by side. That is both the standard and instances of
clinical data. As a example to discuss pros/cons etc.


Sent from my iPhone

On 12 jul 2013, at 11:52, "Luciano, Joanne S." <luciaj2@rpi.edu<mailto:luciaj2@rpi.edu>> wrote:

On Jul 10, 2013, at 11:37 PM, Kerstin Forsberg <kerstin.l.forsberg@gmail.com<mailto:kerstin.l.forsberg@gmail.com>>

Hi Joanne,
I'm intrerested in learning more about SIO and it's potential for clinical data.

Michel is the expert on SIO.  The web page is here:  http://code.google.com/p/semanticscience/wiki/SIO
I can tell you more after we encode the Hamilton Scale.

Thanks very much for the link below. I will pass it along to my student.

Kind regards,

I can think of two related, and quite, different approaches:

- CDISC provide some pieces of standards for questionnaires, such as Hamilton scale (e.g.. the list of text strings to identify different questions http://evs.nci.nih.gov/ftp1/CDISC/Questionnaire/QS%20Terminology.html), A FDA/Phuse project for Semantic Technology work on representing these pieces in RDF (http://cdisc2rdf.com/). CDISC together with TransCelerate BioPharma plan to tie the different pieces of together for measurements and questionaries as so called "Scientific Concepts" as part of thw SHARE project (http://www.cdisc.org/cdisc-share)

- At ICBO eralier this week presented Alan Ruttenberg with collegues in Buffalo an interesting paper on a OBO Foundry based approach for another clinical instrument, i,e the Mini Mental Scale (MMSE), "Measuring Cognitive Functions: Hurdles in the Development of the NeuroPsychological Testing Ontology" http://www.unbsj.ca/sase/csas/data/ws/icbo2013/papers/research/icbo2013_submission_46.pdf

Kind Regards
2013/7/10 Luciano, Joanne S. <luciaj2@rpi.edu<mailto:luciaj2@rpi.edu>>
Looking for some thoughts on this…

We're creating an ontology for the hamilton depression rating scale (this is the clinical instrument used in all clinical trials of antidepressants).

Would it be good to build this under SIO?

if so, where i think it fits, is under process (the depression treatment is a process)
process-> interaction->observation->

adding sub classes there
    clinical instrument
             Hamilton Depression Rating Scale
                     HDRS 28 Question Version
                           Q1-Depressed mood

does this make sense to you?
do you have a better idea?


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Received on Friday, 12 July 2013 18:40:15 UTC

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