RE: PubChem PD & AD candidates for demo

Thanks Matthias-- I've included them...(everyone should feel free to edit the page as they see fit!)

very interesting story regarding the heart valve 5HT-2b connection...

Eric


-----Original Message-----
From: public-semweb-lifesci-request@w3.org on behalf of Matthias Samwald
Sent: Tue 3/13/2007 3:25 PM
To: public-semweb-lifesci@w3.org
Subject: Re: PubChem PD & AD candidates for demo
 

Two things I would add:

DONEPEZIL (http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3152) One of the most popular and modern Acetylcholineesterase inhibitors in Alzheimers. Also included in one of the Brainpharm demos, if I remember correctly.

MEMANTINE (already listed as a Parkinson's medication) is of interest both for Parkinson's and Alzheimers, see e.g.[1]. If we are still trying to have both diseases covered in the use case, Memantine could be another link between the both.

(I can add this to the wiki, if you like)



[Slightly off-topic]
By the way, on the topic of Parkinson medication, toxicology and drug safety, this might be of interest:
http://www.npr.org/templates/story/story.php?storyId=6718704

Basically it was found that some Parkinson medications cause heart damage, because of agonism at 5HT-2b serotonin receptors [2]. The fact that 5HT-2b agonism causes heart damage was known for some years, and the fact that some medications are 5HT-2b agonists was known for some time -- it just took quite a time until the medical community made the Syllogism that some of these medications can be the cause of observed heart damage in some patient populations. This would be another prime example for the use of Semantic Web technologies, in my opinion.
[/Slightly off-topic]


cheers,
Matthias Samwald

 


[1] Rationale for combination therapy with galantamine and memantine in Alzheimer's disease. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16809811&query_hl=5&itool=pubmed_docsum

[2] Drugs and Valvular Heart Disease
http://content.nejm.org/cgi/content/extract/356/1/6




On Tue, 13 Mar 2007 14:07:43 -0400, Eric Neumann wrote:
> I've included sometherapeutic candidates from PubChem at... 
> http://esw.w3.org/topic/HCLSIG/DEMO/ChemicalAgents
>
>
> These are linked from a bullet in...
> http://esw.w3.org/topic/HCLSIG_BioRDF_Subgroup/Demo_Thoughts
>
>
> Eric