- From: Nigam Shah <nigam@stanford.edu>
- Date: Thu, 8 Dec 2005 10:46:47 -0800
- To: <public-semweb-lifesci@w3.org>
Hi Everyone, I am a Post-doc with the National Center for Bioedical Ontology (http://bioontology.org) at Stanford, which works to develop innovative technology and methods that allow scientists to create, disseminate, and manage biomedical information and knowledge in machine-processable form. My PhD work was focused on developing methods for the representation, manipulation and conceptual integration of diverse biological data with prior biological knowledge to facilitate both, interpretation of data and evaluation of alternative hypotheses (or models). I am interested in understanding the ability of the Semantic Web to support such methods. Regards, Nigam. [Detail Background & Interest] In collaboration with Stephen Racunas, I have developed the HyBrow (Hypothesis Browser) system as a prototype tool for designing hypotheses and evaluating them for consistency with existing knowledge. HyBrow consists of a conceptual framework with the ability to represent diverse biological information sources, an ontology for describing biological processes at different levels of detail, a database to query information in the ontology, and programs to design, evaluate and revise hypotheses. HyBrow allows the integration of different types of biological information, such as gene expression data, gene and protein sequence homologies, as well as data on protein interactions and modifications for the purpose of evaluating alternative hypotheses about biological processes. The prototype is available at http://www.hybrow.org. In order to for tools like HyBrow to be widely useful, knowledgebases [or a semantic web!], which can provide structured descriptions of biological entities and processes in a consistent and sufficiently expressive manner is an extant need. I am interested in understanding the ability of the Semantic Web to support such a need. Apart from my research work, I have experience managing large scale microarray data, teaching microarray data analysis techniques to faculty and students, and have trained in medicine. I am also familiar with basic concepts and methods in mathematical modeling of biological systems. --------------------------------- Nigam Shah Postdoctoral Fellow, Stanford Medical Informatics. Ph: 650.725.6236 Web: www.stanford.edu/~nigam/ ---------------------------------
Received on Friday, 9 December 2005 09:14:43 UTC