X-UA-Compatible meta tag and Assistive Technologies

Hi,

I am working on few applications that re-renders in IE Edge in the
Emulation mode (IE 5, 7, 8, 9) as they have the X-UA-Compatible meta tags.

Has anyone noticed any issues screen readers or other assistive
technologies face due to this?

   - Visually there are CSS styling differences between Edge and the older
   IE versions
   - Deprecated HTML tags are adjusted by the IE version.

Has there been any research done in this area to refer to about there
interaction with ATs?

I really appreciate any feedback on this.

Thanks,
Herin