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Re: : KB note

From: Kei Cheung <kei.cheung@yale.edu>
Date: Tue, 27 May 2008 16:47:23 -0400
To: "Huajun Chen@Zhejiang University" <huajunsir@gmail.com>
Cc: 'Matthias Samwald' <samwald@gmx.at>, public-semweb-lifesci@w3.org, kc28@email.med.yale.edu, 'Tim Clark' <twclark@nmr.mgh.harvard.edu>
Message-id: <483C735B.5050607@yale.edu>

I agree. -Kei

Huajun Chen@Zhejiang University wrote:
> Another challenge is cross-language data integration, which is actually a
> job that ontology should do. 
> Best wishes, huajun
> -----ʼԭ-----
> : public-semweb-lifesci-request@w3.org
> [mailto:public-semweb-lifesci-request@w3.org]  Matthias Samwald
> ʱ: 2008526 21:22
> ռ: kc28@email.med.yale.edu; Tim Clark
> : M. Scott Marshall; public-semweb-lifesci@w3.org
> : Re: KB note
>> Speaking of national boundaries, I wonder if alternative medicine (e.g., 
>> herbal
>> medicine) would also be of interest to this community. For example, 
>> Huperzine
>> is a drug derived from the herb Huperzia serrata. I also wonder if there 
>> are
>> hypotheses regarding the study of herbs in the possible treatment of
>> neurological diseases.
> I would also be very motivated to help in this kind of research. 
> Specifically, Huperzine A would be a very interesting use-case for our 
> developments. It is a herbal compound with a history in folk medicine and is
> available OTC in most countries, yet it rivals the effectiveness of 
> currently leading Alzheimer medications such as Tacrine. It also has a dual 
> mode of action that does not only involve acetylcholinesterase inhibition, 
> but also modulation of the NMDA receptor. The implications of this for the 
> treatment of Alzheimer's are still a rather hot topic.
> The integration of knowledge from traditional medicine, plant 
> taxonomy/phylogeny/biochemistry and receptor binding databases (PDSP Ki 
> database, IUPHAR) could lead to the identification of some extremely novel 
> therapeutic strategies. Finding candidate molecules in such a way might be 
> much more effective than weeding through libraries of compounds generated by
> combinatorial synthesis etc. The challenge lies in the integration of some 
> very heterogenous datasets that come from vastly different disciplines, 
> which is exactly the field of research where Semantic Web technologies are 
> most effective.
> I guess the major problem for this kind of research is that there are no 
> funding programmes that span China, the US and Asia...
> Cheers,
> Matthias Samwald
> DERI Galway, Ireland // Semantic Web Company, Austria
> http://www.deri.ie/
> http://www.semantic-web.at/
Received on Tuesday, 27 May 2008 20:48:07 UTC

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