- From: Kashyap, Vipul <VKASHYAP1@PARTNERS.ORG>
- Date: Wed, 13 Dec 2006 20:20:12 -0500
- To: "June Kinoshita" <junekino@media.mit.edu>
- Cc: <public-semweb-lifesci@w3.org>
> Re integrating our AD use case with a PD use case, I could imagine > one where a PD researcher is investigating whether an immunization > approach could work for PD. There are some strong parallels between > AD and PD (and indeed, there is significant co-morbidity and > overlapping pathology). PD is characterized by aggregates of alpha- > synuclein, and some researchers have reported that there are soluble > oligomers of alpha-synuclein that may be toxic. The brain regions > that express alpha-synuclein are different than those that express > Abeta (I believe the Mouse BIRN has some gorgeous images of GFP- > tagged alpha-synuclein), there are some interesting mouse models for > investigating the interaction between alpha-syn and Abeta, and there > may well be some preclinical studies under way to try alpha-syn > immunization. If so, I'm sure those folks are carefully watching what > is going on in AD. [VK] I find the possibility that semantic web technologies can enable the discovery and validation of a scientific hypothesis, e.g., the interaction between alpha-syn and Abeta and the potential relationship between AD and PD very intriguing and exciting! ---Vipul
Received on Thursday, 14 December 2006 01:23:00 UTC