- From: Eric Neumann <eneumann@teranode.com>
- Date: Sat, 17 Feb 2007 16:51:00 -0500
- To: "Alan Ruttenberg" <alanr@mumble.net>
- cc: public-hcls-dse@w3.org
Received on Saturday, 17 February 2007 21:51:19 UTC
Alan, Here is a draft for a possible clinical angle to the HCLS demo... 1. Extend PD/AD demo to include clinical study data from patients, using DSE's draft RDF model based on CDISC's SDTM standard: http://esw.w3.org/topic/HCLSIG/Drug_Safety_and_Efficacy/SDTM/Example_N3#Clinical_Data 2. Compile patient data for either: a. disease progression - base on symptomatic terminology such as EOAD or MCI for AD, and tremor, hyperkinetic dysarthia, or bradykinesia for PD or b. new drug trial - dosing, symptomatic response patterns over time + any observed adverse events (AE) 3. If drug trial, then links to PubChem drug information would be useful: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pccompound - for AD: Cognex, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2723754 (images- http://pubchem.ncbi.nlm.nih.gov/image/structurefly.cgi?cid=2723754) - for PD: Cogentin, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441352 or Piribedil, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=198284 4. Use either set of data to show trends using a simple graph visualization (generic table to graph tool?) -Eric
Received on Saturday, 17 February 2007 21:51:19 UTC