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RE: [COI] CT#8 Drug Information Needed for Test Case Query

From: <helen.chen@agfa.com>
Date: Thu, 12 Jun 2008 10:02:27 -0400
To: "R.Cornet@amc.uva.nl" <R.Cornet@amc.uva.nl>
Cc: "public-semweb-lifesci@w3.org" <public-semweb-lifesci@w3.org>, public-semweb-lifesci-request@w3.org
Message-ID: <OF9B9DAF8F.16C5A55C-ON85257466.004C07EC-85257466.004D21AF@agfa.com>
Ronald

I checked RxNav and it is a good tool to get most of information we needed 
for the COI test case. 

I will check the mapping between RxNorm ingredients and SNOMED to see how 
we can get the link between, for example "anticoagulants" to detailed drug 
names in RxNORM. 

Thanks for the pointer and good suggestions.

Helen





"Ronald Cornet" <r.cornet@amc.uva.nl> 
Sent by: public-semweb-lifesci-request@w3.org
11/06/2008 02:22 PM
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"R.Cornet@amc.uva.nl" <R.Cornet@amc.uva.nl>


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RE: [COI] CT#8 Drug Information Needed for Test Case Query







Helen,
 
Looking at RxNorm via RxNav http://mor.nlm.nih.gov/download/rxnav/
Here the brand names below can be mapped to ingredients.
 
Looking up the ingredients in SNOMED shows their classes.
 
So it seems that adequately combining the two can do the job.
 
Regards, Ronald
 
###############################################################
Ronald Cornet, PhD                    email: R.Cornet@amc.uva.nl
dept. of Medical Informatics          phone: +31 (0)20 566 5188
Academic Medical Center, Room J1B-115 fax:   +31 (0)20 691 9840
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From: public-semweb-lifesci-request@w3.org 
[mailto:public-semweb-lifesci-request@w3.org] On Behalf Of 
helen.chen@agfa.com
Sent: Wednesday, June 11, 2008 16:34
To: public-semweb-lifesci@w3.org
Subject: [COI] CT#8 Drug Information Needed for Test Case Query


Eric 

As a minimal requirement to get the test case working In the CT#8 [1], we 
need to identify the following drug information.  I did some text search 
in your Medicaiton_DE.txt [2] file and found some examples of drug names 
under each category 

1. Metfomin, Insulin secretagogue, or Alpha-glucosidase inhibitors 
drug names: Metformin, Repaglinide, Gliclazide, Glipizide, Acarbose, 
Miglitol 
2. Insulin therapy 
drug names: Aimsco Insulin Syringe, 
3. Rosiglitazone or Proglitazone 
drug names: Avandia, Actos 
4. corticosteriods treatment 
drug names: Prelone, Medrol, Deltasone, Kenalog, etc 
5.  weightloss drugs 
drug names: Xenical, Meridia, Tenuate, Tepanil, Adipex-P, Fastin, 
Phentermine HCl , etc 
6. nonsteroidal anti-inlammatory drugs 
drug names: Ibuprogen, Naproxen Sodium , Diclofenac Potassium, Diclofenac 
Sodium, etc 
7. anticoagulants 
drug names: Coumadin, Plavix, Heparin, etc 
8. uricosuric medication 
drug names: Benuryl, Benemid, Probalan, Anturane 
  

Your Medication.DE file seems to contain drug name and package 
information, but as you can see, there is no "drug" class relationship 
that represents the above relationship.  I doubt we can find such 
categorization relationship in RxNorm.   

For the demonstration purpose, we can construct a small "drug" ontology to 
cover the above concepts and drug names.   

But the ideal way is to use an existing and well developed drug ontology 
for this purpose.   

Does anyone on the list know such ontology?

Kind Regards,


[1] 
http://esw.w3.org/topic/HCLS/ClinicalObservationsInteroperability/SPARQL8.html 

[2] http://www.w3.org/2008/04/DiabeticPatientsDataSet/Medication_DE.txt 


Helen Chen | Agfa HealthCare
Senior Researcher | HE/Advanced Clinical Applications Research
T  +1 519 746 6210 Ext.3186 | M  +1 519 498 6244

Agfa HealthCare Inc., 455 Phillip Street, Waterloo, ON N2L 3X2, Canada
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Received on Thursday, 12 June 2008 14:03:16 GMT

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