- From: Jim Hendler <hendler@cs.umd.edu>
- Date: Wed, 25 Sep 2002 22:41:30 -0400
- To: webont <www-webont-wg@w3.org>
- Message-Id: <p05111729b9b8228bde1d@[129.2.177.222]>
In a separate conversation with Chris Welty, he asked me about the importing issue and asked if I had an example. Since I was in the middle of writing one up for a scientific publication, I did some cutting and pasting to create a realistic use case -- here it is (slightly edited so I can use it in public) > >Seriously, you catch me at a good time because I'm just in the >middle of writing up an example for <name of publication>. Here's >roughly how it goes: > >There exists an ontology for cancer that the NCBI (National Center >for Bio Informatics) maintains. They create instances like against >an ontology that defines classes like "oncogene" (note that I >haven't fixed the characters to be legal XML - we have a >preprocessor that does that in practice) > >><Oncogene rdf:ID="Oncogene, MYC"> >> <Found_In_Organism rdf:ID="Human"> >> </Found_In_Organism> >> <Gene_Has_Function rdf:ID="Gene Transcription"> >> </Gene_Has_Function> >> <Gene_Has_Function rdf:ID="Transcriptional Regulation"> >> </Gene_Has_Function> >> <In_Chromosomal_Location rdf:ID="8q24"/> >> <Gene_Associated_With_Disease rdf:ID="Burkitt's Lymphoma"> >> </Gene_Associated_With_Disease> >></Oncogene> > > >Other people now link to this - for example, suppose you are writing >a paper on "burkitt's lymphoma" - if you link to >"http://.../thisdocument#burkitts_lymphoma" then you are agreeing to >THIS use of that term. Meanwhile, someone working on a database >has a sequence that is part of gene 8, so he links it to :8q24 (not >the English term, the URI). Turns out another thing linked to :8q24 >is a locus called PVT1, and the authors of a paper entitled >"Rearrangement of a DNA sequence homologous to a cell-virus junction >fragment in several Moloney murine leukemia virus-induced rat >thymomas" [1] had their paper linked (by someone else actually) to >PVT1. > >So we now have a chain > >MYC -- associated with disease --> Burkitts >MYC -- chromosomal_location --> 8q24 >PVT1 -- location on --> 8q24 >(paper title) -- paperDescribes --> PVT1 > >Thus, the research working on Burkitts, can have an agent that finds >this paper, even though the words burkitt, lymphoma, 8q24 and PVT1 >don't appear anywhere in the paper. A query like "Is anyone working >on a paper that describes the locus of the chromosone associated >with Burkitt's Lymphoma" becomes realistic solvable, by the magic of >web links. > >Was the ontology important? Absolutely, it provided the means by >which the person who described MYC got it right, and it provided the >vital link between 8q24 and burkitt's lymphoma. However, the >remainder of the work was in the agreements represented by the links >- so the person describing the paper didn't have to know about the >ontology, nor did the person sequencing 8q24. Further, maybe this >is linked to other ontologies that we don't care about in this >example - if we have to import everything to do examples like this >we lose scaleability. > >BUT REMEMBER "Hendler's Law:" On the Web there is no 'THE'. > >Thus, there are many other uses of this same ontology that >absolutely requires the semantic entailments and etc. and for those >we provide "imports" - I want to make sure that I can do those >without breaking this, and this without breaking those. > [1] Proc Natl Acad Sci U S A 1984 Jan;81(1):38-42; Lemay G, Jolicoeur P. -- see http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&uid=84119459&Dopt=r -- Professor James Hendler hendler@cs.umd.edu Director, Semantic Web and Agent Technologies 301-405-2696 Maryland Information and Network Dynamics Lab. 301-405-6707 (Fax) Univ of Maryland, College Park, MD 20742 240-731-3822 (Cell) http://www.cs.umd.edu/users/hendler
Received on Wednesday, 25 September 2002 22:41:36 UTC