- From: Matt Halstead <matt.halstead@auckland.ac.nz>
- Date: Tue, 20 Dec 2005 11:08:14 +1300
- To: www-rdf-validator@w3.org
report=Rdf validator won't draw graphs of the following RDF document.
RDF=<?xml version="1.0">
<?xml version="1.0"?>
<rdf:RDF
xmlns:biopax="http://www.biopax.org/release/biopax-level2.owl#"
xmlns="http://www.cellml.org/ontologies/cAMP_PKA_Cascade#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:psimi="http://www.biopax.org/external/psimi#"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:daml="http://www.daml.org/2001/03/daml+oil#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xml:base="http://www.cellml.org/ontologies/cAMP_PKA_Cascade">
<owl:Ontology rdf:about="">
<owl:imports rdf:resource="http://www.biopax.org/release/biopax-
level2.owl"/>
<owl:imports rdf:resource="http://www.biopax.org/external/psimi"/>
</owl:Ontology>
<biopax:protein rdf:ID="active_gi"/>
<biopax:physicalEntityParticipant rdf:ID="reaction_3_active_ac">
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="active_ac"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
<biopax:protein rdf:ID="inactive_pka"/>
<biopax:protein rdf:ID="pp2a"/>
<biopax:physicalEntityParticipant rdf:ID="reaction_13_active_PKA">
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="active_pka"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
<biopax:smallMolecule rdf:ID="adrenaline"/>
<biopax:biochemicalReaction rdf:ID="formation_of_active_gs">
<biopax:PARTICIPANTS>
<biopax:physicalEntityParticipant
rdf:ID="reaction_7_inactive_gs">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="gs">
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>also termed inactive_gs in the context of this model.</
rdfs:comment>
</biopax:protein>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:PARTICIPANTS>
<biopax:LEFT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_7_adrenaline_beta_2_ar_complex">
<biopax:PHYSICAL-ENTITY>
<biopax:complex rdf:ID="adrenaline_beta_2_ar_complex"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>Adrenaline needs to be bound to the beta 1 adrenaergic
receptor before it can bind to the Gs. So this is a reactant.</
rdfs:comment>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant rdf:ID="reaction_7_active_gs">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="active_gs">
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>This is an abstraction on the activation inactivation
cycle of Gs.</rdfs:comment>
</biopax:protein>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
<biopax:LEFT rdf:resource="#reaction_7_inactive_gs"/>
<biopax:PARTICIPANTS>
<biopax:physicalEntityParticipant
rdf:ID="reaction_7_adrenaline_beta_1_ar_complex">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:complex rdf:ID="adrenaline_beta_1_ar_complex"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:PARTICIPANTS>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>This is really the formation of active_gs from inactive gs in
the model.</rdfs:comment>
</biopax:biochemicalReaction>
<biopax:physicalEntityParticipant
rdf:ID="reaction_1_adrenaline_beta_1_ar_complex">
<biopax:PHYSICAL-ENTITY
rdf:resource="#adrenaline_beta_1_ar_complex"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
<biopax:biochemicalReaction
rdf:ID="formation_of_adrenaline_beta_2_ar_complex">
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_2_beta_2_ar">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="beta_2_ar"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_2_adrenaline">
<biopax:PHYSICAL-ENTITY rdf:resource="#adrenaline"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_2_adrenaline_beta_2_ar_complex">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY
rdf:resource="#adrenaline_beta_2_ar_complex"/>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
</biopax:biochemicalReaction>
<biopax:physicalEntityParticipant rdf:ID="reaction_3_ATP">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:smallMolecule rdf:ID="ATP"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
<biopax:physicalEntityParticipant rdf:ID="reaction_3_cAMP">
<biopax:PHYSICAL-ENTITY>
<biopax:smallMolecule rdf:ID="cAMP"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
<biopax:physicalEntityParticipant rdf:ID="reaction_4_active_ac">
<biopax:PHYSICAL-ENTITY rdf:resource="#active_ac"/>
</biopax:physicalEntityParticipant>
<biopax:protein rdf:ID="PDE"/>
<biopax:physicalEntityParticipant rdf:ID="reaction_0_ach">
<biopax:PHYSICAL-ENTITY>
<biopax:smallMolecule rdf:ID="ACH"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
<biopax:biochemicalReaction rdf:ID="formation_of_AMP">
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_12_cAMP">
<biopax:PHYSICAL-ENTITY rdf:resource="#cAMP"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:PARTICIPANTS>
<biopax:physicalEntityParticipant rdf:ID="reaction_12_pde">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY rdf:resource="#PDE"/>
</biopax:physicalEntityParticipant>
</biopax:PARTICIPANTS>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>The cycling out of cAMP by PDE.</rdfs:comment>
<biopax:RIGHT>
<biopax:physicalEntityParticipant rdf:ID="reaction_12_AMP">
<biopax:PHYSICAL-ENTITY>
<biopax:smallMolecule rdf:ID="AMP"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
</biopax:biochemicalReaction>
<biopax:biochemicalReaction rdf:ID="formation_of_active_pka">
<biopax:LEFT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_14_inactive_pka">
<biopax:PHYSICAL-ENTITY rdf:resource="#inactive_pka"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_14_camp">
<biopax:PHYSICAL-ENTITY rdf:resource="#cAMP"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_14_active_pka">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY rdf:resource="#active_pka"/>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>reaction 14</rdfs:comment>
</biopax:biochemicalReaction>
<biopax:protein rdf:ID="l_type_calcium_channel"/>
<biopax:biochemicalReaction
rdf:ID="formation_of_phosphorylated_active_l_type_calcium_channel">
<biopax:LEFT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_13_l_type_calcium_channel">
<biopax:PHYSICAL-ENTITY
rdf:resource="#l_type_calcium_channel"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_13_phosphorylated_active_l_type_calcium_channel">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein
rdf:ID="phosphorylated_active_l_type_calcium_channel"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
<biopax:PARTICIPANTS rdf:resource="#reaction_13_active_PKA"/>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>Activation of the l type calcium channel by phosphorylation.</
rdfs:comment>
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_13_phospahte">
<biopax:PHYSICAL-ENTITY>
<biopax:smallMolecule rdf:ID="phosphate"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
</biopax:biochemicalReaction>
<biopax:catalysis
rdf:ID="catalysis_by_ach_m2_complex_of_formation_of_active_gi">
<biopax:CONTROLLED>
<biopax:biochemicalReaction rdf:ID="formation_of_active_gi">
<biopax:PARTICIPANTS>
<biopax:physicalEntityParticipant
rdf:ID="reaction_10_ach_m2_complex">
<biopax:PHYSICAL-ENTITY>
<biopax:complex rdf:ID="ach_m2_complex"/>
</biopax:PHYSICAL-ENTITY>
<rdfs:comment rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>The enzyme for this reaction</rdfs:comment>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:PARTICIPANTS>
<biopax:LEFT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_10_inactive_gi">
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="inactive_gi"/>
</biopax:PHYSICAL-ENTITY>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_10_active_gi">
<biopax:PHYSICAL-ENTITY rdf:resource="#active_gi"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
</biopax:biochemicalReaction>
</biopax:CONTROLLED>
<biopax:CONTROLLER rdf:resource="#reaction_10_ach_m2_complex"/>
</biopax:catalysis>
<biopax:physicalEntityParticipant rdf:ID="reaction_1_adrenaline">
<biopax:PHYSICAL-ENTITY rdf:resource="#adrenaline"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
<biopax:catalysis rdf:ID="catalysis_of_formation_of_AMP">
<biopax:CONTROLLED rdf:resource="#formation_of_AMP"/>
<biopax:CONTROLLER rdf:resource="#reaction_12_pde"/>
</biopax:catalysis>
<biopax:biochemicalReaction
rdf:ID="formation_of_adrenaline_beta_1_ar_complex">
<biopax:RIGHT
rdf:resource="#reaction_1_adrenaline_beta_1_ar_complex"/>
<biopax:LEFT rdf:resource="#reaction_1_adrenaline"/>
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_1_beta_1_ar">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="beta_1_ar"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
</biopax:biochemicalReaction>
<biopax:biochemicalReaction rdf:ID="formation_of_cAMP">
<biopax:RIGHT rdf:resource="#reaction_3_cAMP"/>
<biopax:PARTICIPANTS rdf:resource="#reaction_3_active_ac"/>
<biopax:LEFT rdf:resource="#reaction_3_ATP"/>
</biopax:biochemicalReaction>
<biopax:physicalEntityParticipant rdf:ID="reaction_4_active_gs">
<biopax:PHYSICAL-ENTITY rdf:resource="#active_gs"/>
</biopax:physicalEntityParticipant>
<biopax:physicalEntityParticipant rdf:ID="reaction_4_inactive_ac">
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
<biopax:PHYSICAL-ENTITY>
<biopax:protein rdf:ID="inactive_ac"/>
</biopax:PHYSICAL-ENTITY>
</biopax:physicalEntityParticipant>
<biopax:smallMolecule rdf:ID="extracellular_ca"/>
<biopax:physicalEntityParticipant rdf:ID="reaction_4_active_gi">
<biopax:PHYSICAL-ENTITY rdf:resource="#active_gi"/>
</biopax:physicalEntityParticipant>
<biopax:biochemicalReaction rdf:ID="formation_of_active_ac">
<biopax:RIGHT rdf:resource="#reaction_4_active_ac"/>
<biopax:PARTICIPANTS rdf:resource="#reaction_4_active_gs"/>
<biopax:LEFT rdf:resource="#reaction_4_inactive_ac"/>
<biopax:PARTICIPANTS rdf:resource="#reaction_4_active_gi"/>
</biopax:biochemicalReaction>
<biopax:protein rdf:ID="pp1"/>
<biopax:modulation rdf:ID="reaction_4_inactivation_of_ac">
<biopax:CONTROLLER rdf:resource="#reaction_4_active_gi"/>
<biopax:CONTROLLED>
<biopax:catalysis rdf:ID="catalysis_of_formation_of_cAMP">
<biopax:CONTROL-TYPE rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>ACTIVATION</biopax:CONTROL-TYPE>
<biopax:CONTROLLED rdf:resource="#formation_of_cAMP"/>
<biopax:DIRECTION rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>IRREVERSIBLE-LEFT-TO-RIGHT</biopax:DIRECTION>
<biopax:PARTICIPANTS rdf:resource="#reaction_3_active_ac"/>
<biopax:CONTROLLER rdf:resource="#reaction_3_active_ac"/>
</biopax:catalysis>
</biopax:CONTROLLED>
</biopax:modulation>
<biopax:modulation rdf:ID="reaction_4_activation_of_ac">
<biopax:CONTROL-TYPE rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>ACTIVATION</biopax:CONTROL-TYPE>
<biopax:CONTROLLED rdf:resource="#catalysis_of_formation_of_cAMP"/>
<biopax:CONTROLLER rdf:resource="#reaction_4_active_gs"/>
</biopax:modulation>
<biopax:protein rdf:ID="m2"/>
<biopax:biochemicalReaction rdf:ID="formation_of_ach_m2_complex">
<biopax:LEFT>
<biopax:physicalEntityParticipant rdf:ID="reaction_0_m2">
<biopax:PHYSICAL-ENTITY rdf:resource="#m2"/>
</biopax:physicalEntityParticipant>
</biopax:LEFT>
<biopax:RIGHT>
<biopax:physicalEntityParticipant
rdf:ID="reaction_0_ach_m2_complex">
<biopax:PHYSICAL-ENTITY rdf:resource="#ach_m2_complex"/>
<biopax:STOICHIOMETRIC-COEFFICIENT rdf:datatype="http://
www.w3.org/2001/XMLSchema#double"
>1</biopax:STOICHIOMETRIC-COEFFICIENT>
</biopax:physicalEntityParticipant>
</biopax:RIGHT>
<biopax:LEFT rdf:resource="#reaction_0_ach"/>
</biopax:biochemicalReaction>
<biopax:catalysis
rdf:ID="catalysis_by_adrenaline_beta_1_ar_complex_of_formation_of_active
_gs">
<biopax:CONTROLLER
rdf:resource="#reaction_7_adrenaline_beta_1_ar_complex"/>
<biopax:CONTROLLED rdf:resource="#formation_of_active_gs"/>
<biopax:DIRECTION rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>PHYSIOL-LEFT-TO-RIGHT</biopax:DIRECTION>
</biopax:catalysis>
<biopax:catalysis
rdf:ID="catalysis_by_adrenaline_beta_2_ar_complex_of_formation_of_active
_gs">
<biopax:CONTROLLED rdf:resource="#formation_of_active_gs"/>
<biopax:CONTROLLER
rdf:resource="#reaction_7_adrenaline_beta_2_ar_complex"/>
<biopax:DIRECTION rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>PHYSIOL-LEFT-TO-RIGHT</biopax:DIRECTION>
</biopax:catalysis>
<biopax:smallMolecule rdf:ID="intracellular_ca"/>
<biopax:catalysis
rdf:ID="catalysis_of_formation_of_phosphorylated_active_l_type_calcium_c
hannel">
<biopax:CONTROLLED
rdf:resource="#formation_of_phosphorylated_active_l_type_calcium_channel
"/>
<biopax:DIRECTION rdf:datatype="http://www.w3.org/2001/
XMLSchema#string"
>PHYSIOL-LEFT-TO-RIGHT</biopax:DIRECTION>
<biopax:CONTROLLER rdf:resource="#reaction_13_active_PKA"/>
</biopax:catalysis>
</rdf:RDF>
<!-- Created with Protege (with OWL Plugin 2.1, Build 284) http://
protege.stanford.edu -->
Received on Monday, 19 December 2005 22:08:33 UTC