Re: CORD-19 semantic annotations - 11am Tuesday (Boston time) - Jin-Dong Kim (Schedule change)

Hi David,

I would like to join the meeting but I am unable to join the Hangout call because the video call is full with 10.
Can we use some other meeting platform with more connections?

Thanks,
Vinh

> On Apr 21, 2020, at 10:47 AM, David Booth <david@dbooth.org> wrote:
> 
> Last minute schedule change for today's call: Instead of Scott Malec, Jin-Dong Kim will present his work on "An open collaboration for richly annotating Covid-19 Literature".  Slides are here:
> https://urldefense.proofpoint.com/v2/url?u=https-3A__docs.google.com_presentation_d_1ynoe1Xxc-5F-2DrTiebbvvuPBQMaktK-2DDX87McuDVaLbI1g_edit-23slide-3Did.g726dbf02a0-5F0-5F0&d=DwIDaQ&c=3buyMx9JlH1z22L_G5pM28wz_Ru6WjhVHwo-vpeS0Gk&r=ao0HdW4_BSUBmFtYkSUY5HNHmhEUEMBLFy-u4FMLkt8&m=rRtrUOuREZcGoUF677l46sKSQCe3qGQJFjlQTHpEI7k&s=TLzgoWQAHR-uMKRPHbRPpg8cDYS3XeEcAgqsAQoJYjg&e= 
> David Booth
> 
> On 4/20/20 11:56 AM, David Booth wrote:
>> Tomorrow (Tuesday) 11am Boston time Scott Malec will discuss his work on computable knowledge extraction using the CORD-19 dataset that was released by the Allen Institute.
>> We will use this google hangout:
>> https://urldefense.proofpoint.com/v2/url?u=http-3A__tinyurl.com_fhirrdf&d=DwIDaQ&c=3buyMx9JlH1z22L_G5pM28wz_Ru6WjhVHwo-vpeS0Gk&r=ao0HdW4_BSUBmFtYkSUY5HNHmhEUEMBLFy-u4FMLkt8&m=rRtrUOuREZcGoUF677l46sKSQCe3qGQJFjlQTHpEI7k&s=QkufOhCI2BnIKN7ZxwS0x6FmTBNAT_HXcQGGcVq-atE&e= More on Scott's work:
>> https://urldefense.proofpoint.com/v2/url?u=https-3A__github.com_fhircat_CORD-2D19-2Don-2DFHIR_wiki_CORD-2D19-2DSemantic-2DAnnotation-2DProjects-23project-2Dname-2Dcord-2Dsemantictriples&d=DwIDaQ&c=3buyMx9JlH1z22L_G5pM28wz_Ru6WjhVHwo-vpeS0Gk&r=ao0HdW4_BSUBmFtYkSUY5HNHmhEUEMBLFy-u4FMLkt8&m=rRtrUOuREZcGoUF677l46sKSQCe3qGQJFjlQTHpEI7k&s=EXrxlQi3KgJkLSQL8C1tfkjnKNPy46cP4BgRxBPM-RU&e=  We still have time for one other presentation tomorrow about CORD-19 semantic annotation.  If anyone else is ready (with slides) to present for 20 minutes, please let me know.
>> Thanks,
>> David Booth
>> -----------------------------------------------
>> MEETING NOTES 7-Apr-2020
>> Present: David Booth <david@dbooth.org>, Sebastian Kohlmeier <sebastiank@allenai.org>, Lucy Lu Wang <lucyw@allenai.org>, Kyle Lo <kylel@allenai.org>, Jim McCusker <mccusker@gmail.com>, Scott Malec <sam413@pitt.edu>, Guoqian Jiang <jiang.guoqian@mayo.edu>, Todor Primov <todor.primov@ontotext.com>
>> Sebastian: Allen Institute, Semantic Scholar, Non-profit AI institute, w Lucy and Kyle.  Engaged in COVID-19 because as non-profit could develop a corpus that we can make available.  Created CORD-19 dataset.  Goal: Standardized format that's easy for machines to read, to enable quick analysys of the literature.  Working to extend it.  Weekly updates, but want to get to daily updates.  Want to also get to to entity and relation extraction.
>> Guoqian: Identifiers used?  SHA numbers for full text, but also IDs linked to DOIs and Pubmed IDs.  Should discuss best way to have unique ID for publication.
>> Kyle: Added unique IDs: cord_UID.  SHA is a hash of PDF, and sometimes there are multiple PDFs for a single paper.
>> Jim: DOIs?
>> Lucy: Some papers do not have a DOI.
>> Jim: Building a KG using generalized tools from another projects, used in many domains.  Looking to do drug repurposing using CORD-19.  Using an extract of CORD-19.  Does deep extraction of named entities and relationships.  Use PROV ont and nanopublications, for rich modeling and provenance for probabilistic KG.  Arcs in picture are based on confidence level.  Allows high precision on drugs that have been tested on melanoma before.  Re-applying this to COVID-19.  We focus on open ontologies, and not using FHIR.  Unpublished yet.  Page-rank based analysis of pubmed citation graph, to compute community trust in a paper.
>> Guoqian: What ont?
>> Jim: Drugbank mostly.  Lots of targets.
>> Kyle: Relation-entity set.  Closed set?
>> Jim: We have drug graph, protein-protein interaction, and drugbank has drug-protein interaction.  Molecular interaction.  CTD Comparative Toxinomic Database, Heng Ji Lab database started with it.
>> Kyle: Trying to add more KB entities?
>> Jim: Want to expand the interaction set.  Also entities.  We have all human proteins and drugbank drugs.  If you have a drug with an effect on a target similar protein in COVID-19, will there be hits, directly or indirectly?  To do that, we want to score it also based on confidence in the research.
>> Scott: My research approach is to integrate structured knowledge from literature or other curated sources, and combine with observational data to facilitate more reliable inference.  General idea is that contextual info can help interpret and identify confounders.  Confounders are common causes of the predictor and outcome.  What I did with CORD-19: took pubmed IDs, and found what machine reading performed and created KG.  Machine reading can run for months.  Jim's work on citation analysis is cool.  Using semrep, developed by NLM, over titles and abstracts in pubmed.  Using Pubmed central IDs from metadata table, in beginning of March, 31k papers, with 28k in pubmed central.  Seemed like a good place to start building a KG quickly, to see the big picture quickly.  Pulled 106k semantic predications in the 21k docs, pulled into cytoscape and computed network centrality, and from that ranked. Fitered by biomedicl entities, diseases, syndromes, amino acids, peptides or pharm substances.  Ranked themm by centrality to understnad their importance.  Very prelim analysis.  Interested to see how I might expand on this and learn what others are doing.
>> Guoqian: Can cytoscape support RDF graphs?  David: Yes.  Jim: Yes, and you can form SPARQL queries to extract specific interactions.  Not 1:1 mapping of RDF graph to bio network.
>> Todor: There are different plugins, one is SPARQL endpoint.  Others for other visualizations.  Keep expectations low.
>> Jim: It also includes a knowledge exploration interface, built on cytoscape.js, a re-implementation of cytoscape.  The implementation I'm using has some interface element.
>> Lucy: How does Coronavirus ont relate?
>> Guoqian: Using this ont to annotate the papers.
>> Lucy: Where did that ont come from?
>> Jim: Built using OBO foundries?  Guoqian: Yes.
>> Jim: We use OBO ont.  Oliver has a lot of tools for subsetting and extracting for app ontologies.
>> Guoqian: Also collaborating with Cochrane PICO ontology, devloping COVID-19 PICO ont, specific subtypes of the high level types, eg, subtypes of population with particular co-morbilitidies.  The ont is also avail on github.
>> Guoqian: How to collaborate?  Need a registry for KG from this community?
>> Lucy: Working on semantic annotation of entity and rel.  Lots of people are doing bottom-up annotation, without formal vocab, then linking to UMLS.  But haven't seen COVID-19 ont.
>> Guoqian: Also should look at use cases that different groups have. Community said they want open vocab instead of SNOMED-CT, such as UMLS.
>> Lucy: Also working with a group at AWS, KB of concepts, link to ICD-10 and RXNorm, also lots of requests for protein and interactions.
>> Guoqian: Also procedure datasets.
>> Lucy: What use cases are these projects addressing?
>> Guoqian: For EBMonFHIR, they are focused on review of evidence, and clinical concepts.  Other team looking at using OBO ont to analyse DB to mine underlying mechanisms.  Ideally we should have linkage across vocabularies.  Eg UMLS can link many ont.  But for OBO it might be  a challenge.
>> Jim: From microbio perspectvie, most useful from this group would be having cross mapping from clinical/FHIR/SNOMED-ish world and OBO bio world, with translation between the two.  E.g. I use uniprot IDs.  Is that a problem?  What about drug IDs?  IDs are the hardest part -- agree on some, and mappings for others.
>> Guoqian: If we can provide a list of ont each team prefers, we can discuss.
>> Lucy: Would be great to be able to share annotations.  Centralized vocab?  Central KB?  Use cases are key.
>> Scott: Mapping problems with COVID-19 are same as other mapping problems.  Should have a central place to share projects.  Should keep use cases in mind.
>> Sebastian: Please give us feedback on the dataset!
>> Todor: Focus on specific questions that you want to answer, then map using common IDs to address them.
>> Daniel: What formats?  Right now we're using FHIR.  Use others?
>> Jim: identifier.org might be useful for mapping.
>> David: Useful to have each group present use cases and vocab.
>> We'll meet weekly, same time, 1 hour.  Each group will present their work in more detail, with focus on:
>> what use cases they are addressing; and
>> what vocabularies / ontologies they're using.
>> Each group will present for 20 min presents, 10 min questions.
>> ADJOURNED
>

Received on Tuesday, 21 April 2020 15:10:42 UTC