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Minutes from the 2/24/16 DDI Information task force discussion (content sub group)

From: Richard Boyce <rdb20@pitt.edu>
Date: Sat, 26 Mar 2016 12:01:21 -0400
To: <public-semweb-lifesci@w3.org>, <linikujp@gmail.com>, <brian.lebaron@va.gov>, <BHocum@genelex.com>, <CJVITALE@PARTNERS.ORG>, <Cui.Tao@uth.tmc.edu>, <malone@Pharmacy.arizona.edu>, <daniela.oliveira@insight-centre.org>, <eric@squishymedia.com>, <draper.evan@mayo.edu>, <george.lilly@va.gov>, <gmcevoy@ashp.org>, <jschneider@pobox.com>, <harryh@pitt.edu>, <jeffnielson@gmail.com>, <sundaram.medimmune@gmail.com>, <jschneider@pobox.com>, <jrhorn@u.washington.edu>, <jklimek@ncpdp.org>, <jp@rxdoc.me>, <jmbanda@stanford.edu>, <kak59@pitt.edu>, <kim.nolen@pfizer.com>, <laura.slaughter@gmail.com>, <lori.idemoto@gmail.com>, <peters@pharmacy.arizona.edu>, <maria.herrero@kcl.ac.uk>, <Breitenstein.Matthew@mayo.edu>, <MBrochhausen@uams.edu>, <matthias.samwald@meduniwien.ac.at>, <michel.dumontier@stanford.edu>, <Michael.Miller@systemsbiology.org>, <michael.liebman@ipqanalytics.com>, <mail@jackpo.org>, <nancy@worldvista.org>, <nick.tatonetti@columbia.edu>, <hassanzadeh@us.ibm.com>, <yongqunh@med.umich.edu>, <olivier@nlm.nih.gov>, <beyan@dbis.rwth-aachen.de>, <nytroe@idi.ntnu.no>, <ratnesh.sahay@insight-centre.org>, <rdb20@pitt.edu>, <Freimuth.Robert@mayo.edu>, <Sam.habiel@gmail.com>, <scott.nelson.rx@gmail.com>, <serkanayvaz@gmail.com>, <valerie@genelex.com>, <xjing2007@gmail.com>
Message-ID: <56F6B251.70508@pitt.edu>
(FYI for folks on the public-semweb-lifesci list who are not 
participating in the task force [1])

Hello,

Below I have pasted the minutes from the last meeting of the content 
sub-team for the DDI Minimum Information Model task force [1].  I 
apologize that I was forgot to record the meeting but I have tried to 
write detailed minutes. The full set of minutes for the task force are 
available [2].

1. https://sites.google.com/site/ddikrandir/home/ddi_info_model_taskforce
2. https://goo.gl/TKWfNN

------------


    Minutes for 2/24/2016 (Content subgroup)


In Attendance : Dan Malone, Evan Draper, John Horn, Oktie Hassanzadeh, 
Richard Boyce, Sam Habiel


Meeting recording: None taken (Rich forgot to start the recording, Sorry!)


Meeting:

  *

    Brief discussion of progress on the proposed task force activities:


 1.

    Clarify definitions for the seven minimum information items
    recommended by prior AHRQ drug interaction conference series

      *

        A sub-team has been working on creating definitions. Initial
        ideas have been developed and will be discussed over the next
        month: https://goo.gl/N0MxPd

      *

        Some questions were raised by the sub-team that were discussed
        later during the meeting.


 2.

    Propose additional attributes

      *

        Depends on Activity 1


 3.

    Create deliverablesusing an interesting and non-trivial set of
    potential drug-drug interactions:

      *

        Depends on Activities 1 and 2

 4.

    Create a foundation for further collaborative workby disseminating
    results through an interest group note, a website, and an online
    discussion forum

      *

        Ratnesh Sahay has created a project that will be used for
        advancing development of the interest group note:
        https://github.com/W3C-HCLS/w3c-ddi

         1.

            A very initial outline can be seen here: http://goo.gl/ZMU1Wm

         2.

            All persons who have participated in the calls have been
            listed as contributors for now (in alphabetical order by
            first name). Please email Rich Boyce with spelling
            corrections and the affiliation you would like (or if you
            would like your name removed)

      *

        Scott Nelson submitted a panel proposal on 3/10 to AMIA to
        discuss the topic of including seriousness as a minimum
        information item


  *

    Discussion of what DDI content to include in our deliverables.

      o

        Sub-team members had made progress on suggesting interacting
        pairs based on known issues with DDI evidence and knowledge

          +

            See https://goo.gl/rYpmjt

      o

        Rich created a survey to increase the participation:
        https://pitt.co1.qualtrics.com/jfe/form/SV_0GPfzm7UbGDYV5X

          +

            Survey closes EOB Wednesday 3/30

      o

        It was decided that only one or two PDDIs will be selected for
        each category. The group agreed that, for each PDDI, a decision
        tree will be created that provides 1) information that can help
        contextualize the interaction depending on drug and patient
        factors, 2) management recommendations depending on the
        contextualizing factors in (1), and 3) evidence supporting or
        refuting each scientific claim made for (1)

          +

            Such decision trees have already been created by John Horn
            and Phil Hansten for several interactions as part of Dan
            Malone’s AHRQ grant (R21HS023826).

              #

                These can be used for the project as long as we provide
                citation to the authors and grant.

              #

                These interactions might fit as representative for
                certain information categories. The group agreed that,
                for those cases, additional interactions will be chosen
                to provide heterogeneity

  *

    Discussion of stakeholders

      o

        The question of who the stakeholders are for the min info model
        came up from the Standard sub-team. The content sub-team agreed
        that the stakeholders included primarily the following:

          +

            Clinicians (doctors, nurses, pharmacists, and various
            practitioners) who must use PDDI information to make
            clinical decisions

          +

            Persons who create systems that provide PDDI information to
            clinicians in various settings (e.g., database vendors, drug
            information editorial boards)

          +

            Organizations that provide publicly available lists of
            drug-drug interactions (e.g., developers of RxNorm)

      o

        Clarification of this in writing is planned

  *

    Discussion of use cases:

      o

        Members of the standard sub-team had suggested using Medication
        Reconciliation as a target use case for showing the value of the
        info model (e.g., competency questions). Rich asked the content
        sub-team for comment

          +

            It was agreed that med rec is an important use case but one
            that can probably be broken down into a number of smaller
            use cases depending on the phase of the medication therapy
            process in question (e.g., ordering, consulting, monitoring)

      o

        Clarification of this in writing is planned and also a focused
        discussion at our “all team” meeting in May.

  *

    Action Items

          +

            Rich will merge the final results of the survey on suggested
            PDDIs
            (https://pitt.co1.qualtrics.com/jfe/form/SV_0GPfzm7UbGDYV5X)
            into the google sheet (https://goo.gl/rYpmjt)

          +

            He will then go through and highlight the PDDIs for which
            decision trees have been created as part of Dan Malone’s
            AHRQ grant

          + The next meeting will finalize the list and future meetings
            will finalize decision trees for the chosen interactions. In
            parallel, the standard sub-team will work on representing
            the chosen interactions, seeking feedback as they go.


-- 
Richard D Boyce, PhD
Assistant Professor of Biomedical Informatics
Faculty, Center for Pharmaceutical Policy and Prescribing
Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
University of Pittsburgh
rdb20@pitt.edu
Office: 412-648-9219
Twitter: @bhaapgh
Received on Saturday, 26 March 2016 16:01:58 UTC

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