RE: Standards for inclusion/exclusion criteria ?

Hello Andrea,

in this paper:
Ross J, Tu S, Carini S, Sim I.
Analysis of eligibility criteria complexity in clinical trials.
http://www.ncbi.nlm.nih.gov/pubmed/21347148

we describe the results of analyzing a sample of 1000 eligibility criteria extracted for ClinicalTrials.gov.
(I don't see it in the list generated by Google Scholar.)

Regards,
Simona

________________________________
From: Michel Dumontier [michel.dumontier@gmail.com]
Sent: Tuesday, July 23, 2013 12:43 AM
To: Andrea Splendiani
Cc: Kathrin Dentler; HCLS
Subject: Re: Standards for inclusion/exclusion criteria ?

Google Scholar says:

http://scholar.google.ca/scholar?cites=18026669919486573499&as_sdt=2005&sciodt=0,5&hl=en

m.


On Mon, Jul 22, 2013 at 5:09 PM, Andrea Splendiani <andrea.splendiani@iscb.org<mailto:andrea.splendiani@iscb.org>> wrote:
HI,

thanks and sorry for the late reply. I have been doing a bit of reading.
Let's say I am up2date until more or less the date of your review (2007).

First, I wonder if something new come out since then (rather than evolutions of approaches/standards already existing).

Second, I got the impression that rationales to standardize clinical trials criteria vary a lot. Mining EHRs for candidates has different requirements from criteria re-use, which in turns has different requirements from (trials) discovery.
I was looking for some sampling of criteria in use in clinical trials. Could not find anything (at least open). Does anybody have some pointer in this direction ?


best,
Andrea



Il giorno 15/lug/2013, alle ore 07:21, Kathrin Dentler <k.dentler@vu.nl<mailto:k.dentler@vu.nl>> ha scritto:

> Hi Andrea,
>
> For a first broad overview, this paper is a good starting point:
> Formal representation of eligibility criteria: A literature review
> http://www.sciencedirect.com/science/article/pii/S1532046409001592
>
> For CDISC, there is ongoing work on OWL/RDF formats:
> http://www.cancer.gov/cancertopics/cancerlibrary/terminologyresources/cdisc
> http://kerfors.blogspot.nl/2012/05/semantic-models-for-cdisc-based.html
>
> Best,
> Kathrin
>
>
>
> Op 7/15/13 1:34 AM, Andrea Splendiani schreef:
>> Hi,
>>
>> I was wondering if somebody could provide some pointer to work going on in an area that is related to clinical trials: inclusion and exclusion criteria.
>> (I have followed the recent thread on encoding Hamilton Disease and pointers).
>>
>> In, particular, I am interested in two things:
>> Standards with substantial uptake (sub question: is CDISC's uptake actual or perspective ?).
>>
>> Modeling of inclusion/exclusion criteria, but with a particular twist: not modeling the questions, but the facts that are queried. Basically I am interested in modeling patients and conditions (to the level of detail required "usually" required by clinical trials). The subject itself can be very vast, but is there a framework which provides at least an upper perspective on how to model subjects's features, diseases, interventions, samples (also respect to time) ?
>>
>> Any pointer is welcome!
>>
>> best,
>> Andrea Splendiani
>>
>>
>
>
> --
> Kathrin Dentler
>
> AI Department         |   Department of Medical Informatics
> Faculty of Sciences   |   Academic Medical Center
> Vrije Universiteit    |   Universiteit van Amsterdam
> k.dentler@vu.nl<mailto:k.dentler@vu.nl>       |   k.dentler@amc.uva.nl<mailto:k.dentler@amc.uva.nl>
>
> http://www.few.vu.nl/~kdr250/
>
>





--
Michel Dumontier
Associate Professor of Bioinformatics, Carleton University
Chair, W3C Semantic Web for Health Care and the Life Sciences Interest Group
http://dumontierlab.com