So the subgraph doesn't show *all* paths between the compound and target - just those that meet a level of statistical significance relative to background distributions of path patterns in the dataset (the significance level is tweakable in one of the boxes on the graph). Enclosed is a paper preprint which explains this a bit better! Also with the tool you can just enter either a compound or a target and "virtual screen" targets/compounds to see the most related Thanks for giving it a try! David ____________________________________________________ Dr. David J. Wild, djwild@indiana.edu, http://djwild.info @davidjohnwild Assistant Professor of Informatics & Computing Director, Cheminformatics & Chemogenomics Research Group Indiana University School of Informatics and Computing 901 E 10th St Rm 207, Bloomington, IN 47408 Tel. +1 812 856 1848 On Tue, Jun 12, 2012 at 1:10 PM, Oliver Ruebenacker <curoli@gmail.com>wrote: > Hello David, > > On Tue, Jun 12, 2012 at 12:58 PM, David Wild <djwild@indiana.edu> wrote: > > Here it is -- bad name lookup on our part for sulfuric acid - using CID > > instead 1118 > > > > > http://cheminfov.informatics.indiana.edu:8080/slap/slap.jsp?cid=1118&gene=Insulin > > > > Note the direct relationship is removed in the subgraph / calculation to > > show indirect prediction. > > Wouldn't you expect a bigger graph for a molecule that interacts > with many targets? > > Take care > Oliver > > -- > Oliver Ruebenacker > Bioinformatics Consultant ( > http://www.knowomics.com/wiki/Oliver_Ruebenacker) > Knowomics, The Bioinformatics Network (http://www.knowomics.com) > SBPAX: Turning Bio Knowledge into Math Models (http://www.sbpax.org) >
Received on Tuesday, 12 June 2012 17:47:21 UTC