- From: Richard Boyce <rdb20@pitt.edu>
- Date: Thu, 19 Jul 2012 14:10:42 -0400
- To: "Lin MD, Simon" <LINMD.SIMON@mcrf.mfldclin.edu>
- CC: "Freimuth, Robert, Ph.D." <Freimuth.Robert@mayo.edu>, "public-semweb-lifesci@w3.org" <public-semweb-lifesci@w3.org>
- Message-ID: <50084DA2.8020309@pitt.edu>
Hi Simon, I like your idea. If I understand your request, it should be
as simple as adding " ?spl dailymed:activeMoiety ?drug." to the query:
SELECT DISTINCT ?drug ?setId ?rxcuiDrugProduct ?sectionTag ?sectionText
WHERE {
?pharmgxData dailymed:pharmgxBiomarker "CYP2D6".
?pharmgxData dailymed:setId ?setId.
?pharmgxData dailymed:SPLSection ?sectionTag.
?spl dailymed:setId ?setId.
?spl dailymed:activeMoiety ?drug.
?spl ?sectionTag ?sectionText.
?spl dc:subject ?rxcuiDrugProduct.
} LIMIT 1
FYI: Near future work will bring drug class info per NDFRT into
linkedSPLs and map the biomarkers to PRO and Uniprot. I think that
things will only get more when we start playing with federated queries.
-R
On 07/19/2012 01:11 PM, Lin MD, Simon wrote:
>
> Bob, I completely agree. Given the sophisticated layout options
> available in Cytoscape, that could be the way to go for visualization!
> -Simon
>
> *From:*Freimuth, Robert, Ph.D. [mailto:Freimuth.Robert@mayo.edu]
> *Sent:* Thursday, July 19, 2012 12:09 PM
> *To:* Lin MD, Simon; rdb20@pitt.edu; public-semweb-lifesci@w3.org
> *Subject:* RE: Updated Invitation: Pharmacogenomics for Drug Discovery
> @ Thu 2012-07-19 11:00 - 12:00 (public-semweb-lifesci@w3.org)
>
> > Based on the loaded data, can we make a graph showing the complex
> relationship between drugs and biomarkers (n-to-n)?
>
> I think this would be relatively easy to do with Cytoscape (following
> a trivial transform of the data), but the semweb gurus probably know
> of a way to do this natively using the RDF.
>
> Thanks,
> Bob
>
> ------------------------------------------------------------------------
>
> *From:*public-semweb-lifesci-request@listhub.w3.org
> <mailto:public-semweb-lifesci-request@listhub.w3.org>
> [mailto:public-semweb-lifesci-request@listhub.w3.org]
> <mailto:[mailto:public-semweb-lifesci-request@listhub.w3.org]> *On
> Behalf Of *Lin MD, Simon
> *Sent:* Thursday, July 19, 2012 12:01 PM
> *To:* rdb20@pitt.edu <mailto:rdb20@pitt.edu>;
> public-semweb-lifesci@w3.org <mailto:public-semweb-lifesci@w3.org>
> *Subject:* RE: Updated Invitation: Pharmacogenomics for Drug
> Discovery @ Thu 2012-07-19 11:00 - 12:00
> (public-semweb-lifesci@w3.org <mailto:public-semweb-lifesci@w3.org>)
>
> Richard,
>
> Fabulous results! Sorry I was unable to make the call today.
>
> For “3) drug product with CYPD6", can you make the query to show
> the drug names? Right now, it is showing a link.
>
> Here is a scientific question to make it more interesting:
>
> Based on the loaded data, can we make a graph showing the complex
> relationship between drugs and biomarkers (n-to-n)? The drugs and
> biomarkers can be nodes. I suspect a CYP gene will be a hub to
> many drugs. For drug nodes, we can color code them with different
> therapeutic areas.
>
> What do you think?
>
> Simon
>
> ==================================================
>
> Simon Lin, MD
>
> Director, Biomedical Informatics Research Center
>
> Marshfield Clinic Research Foundation
>
> 1000 N Oak Ave, Marshfield, WI 54449
>
> Office 715-221-7299
>
> Lin.Simon@mcrf.mfldclin.edu <mailto:Lin.Simon@mcrf.mfldclin.edu>
>
> www.marshfieldclinic.org/birc <http://www.marshfieldclinic.org/birc>
>
> For scheduling assistance, please contact
>
> Crystal Gumz, Administrative Secretary
>
> gumz.crystal@mcrf.mfldclin.edu <mailto:gumz.crystal@mcrf.mfldclin.edu>
>
> 715-221-6403
>
> *From:*Richard Boyce [mailto:rdb20@pitt.edu]
> <mailto:[mailto:rdb20@pitt.edu]>
> *Sent:* Thursday, July 19, 2012 9:29 AM
> *To:* public-semweb-lifesci@w3.org
> <mailto:public-semweb-lifesci@w3.org>
> *Subject:* Re: Updated Invitation: Pharmacogenomics for Drug
> Discovery @ Thu 2012-07-19 11:00 - 12:00
> (public-semweb-lifesci@w3.org <mailto:public-semweb-lifesci@w3.org>)
>
> Re: "I also want to talk about making that list of FDA labels that
> containing PGx info."...
>
> If its of interest, I can share my initial load and mapping of the
> data from the FDA's pharmacogenomic biomarker table
> <http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm>
> <http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm>
> into linkedSPLs. You can test it out now....
>
> INSTRUCTIONS:
> 1) go to <http://dbmi-icode-01.dbmi.pitt.edu:8080/sparql>
> <http://dbmi-icode-01.dbmi.pitt.edu:8080/sparql>
> 2) enter the following in the field "Default IRI":
> http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/>
> 3) Delete the text in the query box
> 4) enter in any of test of a sample query below (the text in
> between dashed lines)
> 5) to enter a new query, just use the back button, delete the olde
> query, and enter the new one.
>
> Example queries:
>
> 1) show the entire FDA pharmgx table:
>
> ---------------
>
> PREFIX prv: <http://purl.org/net/provenance/ns#>
> <http://purl.org/net/provenance/ns>
> PREFIX dc: <http://purl.org/dc/elements/1.1/>
> <http://purl.org/dc/elements/1.1/>
> PREFIX db:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> PREFIX diseasome:
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> PREFIX drugbank:
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> PREFIX prvFiles: <http://purl.org/net/provenance/files#>
> <http://purl.org/net/provenance/files>
> PREFIX foaf: <http://xmlns.com/foaf/0.1/> <http://xmlns.com/foaf/0.1/>
> PREFIX meta:
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata#>
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata>
> PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
> <http://www.w3.org/2000/01/rdf-schema>
> PREFIX obo: <http://purl.obolibrary.org/obo/>
> <http://purl.obolibrary.org/obo/>
> PREFIX ncbit:
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#>
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>
> PREFIX prvTypes: <http://purl.org/net/provenance/types#>
> <http://purl.org/net/provenance/types>
> PREFIX d2r:
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf#>
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf>
> PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
> <http://www.w3.org/2001/XMLSchema>
> PREFIX prvIV: <http://purl.org/net/provenance/integrity#>
> <http://purl.org/net/provenance/integrity>
> PREFIX map:
> <file:/home/rdb20/linkedSPLs/dailymed_d2r_map_config.n3#>
> <file:///%5C%5Chome%5Crdb20%5ClinkedSPLs%5Cdailymed_d2r_map_config.n3>
> PREFIX owl: <http://www.w3.org/2002/07/owl#>
> <http://www.w3.org/2002/07/owl>
> PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
> <http://www.w3.org/1999/02/22-rdf-syntax-ns>
> PREFIX dailymed:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> PREFIX bpRxnorm: <http://purl.bioontology.org/ontology/RXNORM/>
> <http://purl.bioontology.org/ontology/RXNORM/>
>
>
> SELECT DISTINCT * WHERE {
> ?s rdf:type dailymed:pharmgxData.
> ?s dailymed:activeMoiety ?activeMoiety.
> ?s dailymed:activeMoietyRxCUI ?rxNormCUI.
> ?s dailymed:pharmgxBiomarker ?biomarker.
> ?s dailymed:therapeuticApplication ?therapeuticApplication.
> ?s dailymed:setId ?productLabelSetId.
> ?s dailymed:SPLSection ?labelSection.
> } ORDER BY ?productLabelSetId
>
> ---------------
>
> 2) Get sections containing pharmgx recommendations for Psych drugs
>
> ---------------
>
> PREFIX prv: <http://purl.org/net/provenance/ns#>
> <http://purl.org/net/provenance/ns>
> PREFIX dc: <http://purl.org/dc/elements/1.1/>
> <http://purl.org/dc/elements/1.1/>
> PREFIX db:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> PREFIX diseasome:
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> PREFIX drugbank:
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> PREFIX prvFiles: <http://purl.org/net/provenance/files#>
> <http://purl.org/net/provenance/files>
> PREFIX foaf: <http://xmlns.com/foaf/0.1/> <http://xmlns.com/foaf/0.1/>
> PREFIX meta:
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata#>
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata>
> PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
> <http://www.w3.org/2000/01/rdf-schema>
> PREFIX obo: <http://purl.obolibrary.org/obo/>
> <http://purl.obolibrary.org/obo/>
> PREFIX ncbit:
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#>
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>
> PREFIX prvTypes: <http://purl.org/net/provenance/types#>
> <http://purl.org/net/provenance/types>
> PREFIX d2r:
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf#>
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf>
> PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
> <http://www.w3.org/2001/XMLSchema>
> PREFIX prvIV: <http://purl.org/net/provenance/integrity#>
> <http://purl.org/net/provenance/integrity>
> PREFIX map:
> <file:/home/rdb20/linkedSPLs/dailymed_d2r_map_config.n3#>
> <file:///%5C%5Chome%5Crdb20%5ClinkedSPLs%5Cdailymed_d2r_map_config.n3>
> PREFIX owl: <http://www.w3.org/2002/07/owl#>
> <http://www.w3.org/2002/07/owl>
> PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
> <http://www.w3.org/1999/02/22-rdf-syntax-ns>
> PREFIX dailymed:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> PREFIX bpRxnorm: <http://purl.bioontology.org/ontology/RXNORM/>
> <http://purl.bioontology.org/ontology/RXNORM/>
>
> SELECT DISTINCT ?setId ?moiety ?biomarker ?sectionTag ?sectionText
> WHERE {
> ?s dailymed:setId ?setId.
> ?pharmgxData dailymed:setId ?setId.
> ?pharmgxData dailymed:therapeuticApplication ncbit:Psychiatry.
> ?pharmgxData dailymed:activeMoiety ?moiety.
> ?pharmgxData dailymed:pharmgxBiomarker ?biomarker.
> ?pharmgxData dailymed:SPLSection ?sectionTag.
> ?s ?sectionTag ?sectionText.
> }
>
> ---------------
>
> 3) return all setIds and drug product rxcuis for product labels
> that contain sections with FDA pharmgx data for biomarker "CYPD6"
>
> ----------------
> PREFIX prv: <http://purl.org/net/provenance/ns#>
> <http://purl.org/net/provenance/ns>
> PREFIX dc: <http://purl.org/dc/elements/1.1/>
> <http://purl.org/dc/elements/1.1/>
> PREFIX db:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/resource/>
> PREFIX diseasome:
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> <http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/>
> PREFIX drugbank:
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> <http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugbank/>
> PREFIX prvFiles: <http://purl.org/net/provenance/files#>
> <http://purl.org/net/provenance/files>
> PREFIX foaf: <http://xmlns.com/foaf/0.1/> <http://xmlns.com/foaf/0.1/>
> PREFIX meta:
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata#>
> <http://www4.wiwiss.fu-berlin.de/bizer/d2r-server/metadata>
> PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#>
> <http://www.w3.org/2000/01/rdf-schema>
> PREFIX obo: <http://purl.obolibrary.org/obo/>
> <http://purl.obolibrary.org/obo/>
> PREFIX ncbit:
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#>
> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl>
> PREFIX prvTypes: <http://purl.org/net/provenance/types#>
> <http://purl.org/net/provenance/types>
> PREFIX d2r:
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf#>
> <http://sites.wiwiss.fu-berlin.de/suhl/bizer/d2r-server/config.rdf>
> PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
> <http://www.w3.org/2001/XMLSchema>
> PREFIX prvIV: <http://purl.org/net/provenance/integrity#>
> <http://purl.org/net/provenance/integrity>
> PREFIX map:
> <file:/home/rdb20/linkedSPLs/dailymed_d2r_map_config.n3#>
> <file:///%5C%5Chome%5Crdb20%5ClinkedSPLs%5Cdailymed_d2r_map_config.n3>
> PREFIX owl: <http://www.w3.org/2002/07/owl#>
> <http://www.w3.org/2002/07/owl>
> PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
> <http://www.w3.org/1999/02/22-rdf-syntax-ns>
> PREFIX dailymed:
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> <http://dbmi-icode-01.dbmi.pitt.edu/linkedSPLs/vocab/resource/>
> PREFIX bpRxnorm: <http://purl.bioontology.org/ontology/RXNORM/>
> <http://purl.bioontology.org/ontology/RXNORM/>
>
> SELECT DISTINCT ?setId ?rxcuiDrugProduct ?sectionTag ?sectionText
> WHERE {
> ?pharmgxData dailymed:pharmgxBiomarker "CYP2D6".
> ?pharmgxData dailymed:setId ?setId.
> ?pharmgxData dailymed:SPLSection ?sectionTag.
> ?spl dailymed:setId ?setId.
> ?spl ?sectionTag ?sectionText.
> ?spl dc:subject ?rxcuiDrugProduct.
> } LIMIT 10
> ----------------
>
>
> On 07/19/2012 10:09 AM, w3.hcls@gmail.com
> <mailto:w3.hcls@gmail.com> wrote:
>
>
> Microsoft Outlook Web Access:
> https://exchange.pitt.edu/owa?ae=Item&a=open&t=IPM.Schedule.Meeting.Request&id=RgAAAABIJ%2FzGAGFgTKLiK5T2HHYjBwCgDb8iAQTaTJ1WnLL6a2ItAAABKG9eAACUhAUmmNbBR6ow1bEXCKFKACQGgySHAAAL
>
> *This event has been changed.*
>
> more details »
> <https://www.google.com/calendar/event?action=VIEW&eid=dWRsdXAwcDlpcjhvZHBja2RvamdsMW5rMHNfMjAxMjA3MTlUMTUwMDAwWiBwdWJsaWMtc2Vtd2ViLWxpZmVzY2lAdzMub3Jn&tok=MTcjdzMuaGNsc0BnbWFpbC5jb21hZmEzNjhiMjJjYzg1OWE5Y2IzZjcwMmRjYmFmZTU2N2FiMzM0ODNm&ctz=America/New_York&hl=en>
>
> *Pharmacogenomics for Drug Discovery*
>
> *Changed: *Dial-In #: +1.617.761.6200 (Cambridge, MA)
> VoIP address: sip:zakim@voip.w3.org
> <mailto:sip%3Azakim@voip.w3.org>
> Participant Access Code: 4257 ("HCLS")
> IRC Channel: irc.w3.org
> <http://www.google.com/url?q=http%3A%2F%2Firc.w3.org&usd=2&usg=AFQjCNG0MKmcRl77RYagVfKU9ZZl91H2Uw>port
> 6665 channel #HCLS
> IRC Web: http://goo.gl/A6WZn
> Duration: ~1 hour
> Frequency: 1st and 3rd Thursday
> Convener: Michel Dumontier
>
> Hi,
> At today's meeting I hope to discuss some additional sources
> of SNP associations - I've been looking at OMIM, but I would
> love your feedback on other resources. I also want to talk
> about making that list of FDA labels that containing PGx info.
>
> Cheers,
>
> m.
>
> /When/
>
>
>
> Thu 2012-07-19 11:00 – 12:00 Eastern Time
>
> /Calendar/
>
>
>
> public-semweb-lifesci@w3.org <mailto:public-semweb-lifesci@w3.org>
>
> /Who/
>
>
>
> •
>
>
>
> w3.hcls@gmail.com <mailto:w3.hcls@gmail.com>- organizer
>
> •
>
>
>
> public-semweb-lifesci@w3.org <mailto:public-semweb-lifesci@w3.org>
>
> •
>
>
>
> pharmacogenomicspaper@googlegroups.com
> <mailto:pharmacogenomicspaper@googlegroups.com>
>
> Going? *Yes*
> <https://www.google.com/calendar/event?action=RESPOND&eid=dWRsdXAwcDlpcjhvZHBja2RvamdsMW5rMHNfMjAxMjA3MTlUMTUwMDAwWiBwdWJsaWMtc2Vtd2ViLWxpZmVzY2lAdzMub3Jn&rst=1&tok=MTcjdzMuaGNsc0BnbWFpbC5jb21hZmEzNjhiMjJjYzg1OWE5Y2IzZjcwMmRjYmFmZTU2N2FiMzM0ODNm&ctz=America/New_York&hl=en>*-
> **Maybe*
> <https://www.google.com/calendar/event?action=RESPOND&eid=dWRsdXAwcDlpcjhvZHBja2RvamdsMW5rMHNfMjAxMjA3MTlUMTUwMDAwWiBwdWJsaWMtc2Vtd2ViLWxpZmVzY2lAdzMub3Jn&rst=3&tok=MTcjdzMuaGNsc0BnbWFpbC5jb21hZmEzNjhiMjJjYzg1OWE5Y2IzZjcwMmRjYmFmZTU2N2FiMzM0ODNm&ctz=America/New_York&hl=en>*-
> **No*
> <https://www.google.com/calendar/event?action=RESPOND&eid=dWRsdXAwcDlpcjhvZHBja2RvamdsMW5rMHNfMjAxMjA3MTlUMTUwMDAwWiBwdWJsaWMtc2Vtd2ViLWxpZmVzY2lAdzMub3Jn&rst=2&tok=MTcjdzMuaGNsc0BnbWFpbC5jb21hZmEzNjhiMjJjYzg1OWE5Y2IzZjcwMmRjYmFmZTU2N2FiMzM0ODNm&ctz=America/New_York&hl=en>more
> options »
> <https://www.google.com/calendar/event?action=VIEW&eid=dWRsdXAwcDlpcjhvZHBja2RvamdsMW5rMHNfMjAxMjA3MTlUMTUwMDAwWiBwdWJsaWMtc2Vtd2ViLWxpZmVzY2lAdzMub3Jn&tok=MTcjdzMuaGNsc0BnbWFpbC5jb21hZmEzNjhiMjJjYzg1OWE5Y2IzZjcwMmRjYmFmZTU2N2FiMzM0ODNm&ctz=America/New_York&hl=en>
>
> Invitation from Google Calendar
> <https://www.google.com/calendar/>
>
> You are receiving this courtesy email at the account
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> <mailto:public-semweb-lifesci@w3.org> because you are an
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>
> To stop receiving future notifications for this event, decline
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>
>
> --
>
> Richard Boyce, PhD
>
> Assistant Professor of Biomedical Informatics
>
> Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
>
> Scholar, Comparative Effectiveness Research Program
>
> University of Pittsburgh
>
> rdb20@pitt.edu <mailto:rdb20@pitt.edu>
>
> 412-648-9219 (W), 206-371-6186 (C)
>
> Twitter: @bhaapgh
>
> ------------------------------------------------------------------------
>
> The contents of this message may contain private, protected and/or
> privileged information. If you received this message in error, you
> should destroy the e-mail message and any attachments or copies,
> and you are prohibited from retaining, distributing, disclosing or
> using any information contained within. Please contact the sender
> and advise of the erroneous delivery by return e-mail or
> telephone. Thank you for your cooperation.
>
> ------------------------------------------------------------------------
> The contents of this message may contain private, protected and/or
> privileged information. If you received this message in error, you
> should destroy the e-mail message and any attachments or copies, and
> you are prohibited from retaining, distributing, disclosing or using
> any information contained within. Please contact the sender and advise
> of the erroneous delivery by return e-mail or telephone. Thank you for
> your cooperation.
--
Richard Boyce, PhD
Assistant Professor of Biomedical Informatics
Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
Scholar, Comparative Effectiveness Research Program
University of Pittsburgh
rdb20@pitt.edu
412-648-9219 (W), 206-371-6186 (C)
Twitter: @bhaapgh
Received on Thursday, 19 July 2012 18:11:09 UTC