Re: rxnorm mappings in LinkedSPLs

On 07/06/2012 11:10 AM, Lin MD, Simon wrote:
>
> It would be interesting to see a link from the drugs to genes for DNA 
> testing on the FDA label:
>
> http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm
>
This interest has been expressed by some of my colleagues here at Pitt 
as well. Looking at the webpage, it looks like the drug column uses UNII 
preferred terms and the label sections use standard syntax. Not sure 
what is used for the string names in the biomarker and therapeutic area 
columns but they look easy to map - can someone hazard a guess? Once we 
know that, I could script a database table from the html table  of  
ucm083378.htm and create mappings to the referenced sections in 
LinkedSPL for drug products containing the active moieties listed in the 
Drug column. Would interested folks please provide a use case that I 
will use along with the use case for my colleagues to make the mapping 
immediately useful?

best,
-Rich

> Best regards,
>
> Simon
>
> ==================================================
>
> Simon Lin, MD
>
> Director, Biomedical Informatics Research Center
>
> Marshfield Clinic Research Foundation
>
> 1000 N Oak Ave, Marshfield, WI 54449
>
> Office 715-221-7299
>
> Lin.Simon@mcrf.mfldclin.edu
>
> www.marshfieldclinic.org/birc
>
> For scheduling assistance, please contact
>
>       Crystal Gumz, Administrative Secretary
>
>       gumz.crystal@mcrf.mfldclin.edu
>
>       715-221-6403
>
> *From:*Richard Boyce [mailto:rdb20@pitt.edu]
> *Sent:* Friday, July 06, 2012 9:41 AM
> *To:* public-semweb-lifesci@w3.org
> *Subject:* FYI: rxnorm mappings in LinkedSPLs
>
> FYI - for those interested in a linked version of US drug product 
> labeling, I added mappings to RxNORM for active moieties and drug 
> products in the FDA product label data served by LinkedSPLs 
> (http://tinyurl.com/7hyd44g). The mappings go to the Purls served by 
> the Bioportal SPARQL endpoint. Active moieties are mapped using the 
> dailymed:activeMoietyRxCUI property while product mappings use 
> dc:subject. Importantly, SPLs for products containing multiple active 
> moieties (e.g., http://tinyurl.com/78hu8l3) and multiple dose forms 
> (e.g., http://tinyurl.com/7987rjh) seem to be handled correctly. I 
> plan to add drug class mappings w/in the next two weeks. Feedback and 
> suggestions are quite welcome.
>
> kind regards,
> -Rich Boyce
>
>
>
> -- 
> Richard Boyce, PhD
> Assistant Professor of Biomedical Informatics
> Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
> Scholar, Comparative Effectiveness Research Program
> University of Pittsburgh
> rdb20@pitt.edu  <mailto:rdb20@pitt.edu>
> 412-648-9219 (W), 206-371-6186 (C)
> Twitter: @bhaapgh
>
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-- 
Richard Boyce, PhD
Assistant Professor of Biomedical Informatics
Faculty, Geriatric Pharmaceutical Outcomes and Gero-Informatics Research and Training Program
Scholar, Comparative Effectiveness Research Program
University of Pittsburgh
rdb20@pitt.edu
412-648-9219 (W), 206-371-6186 (C)
Twitter: @bhaapgh