Re: BioRDF telcon on Monday at 11AM EDT / 5PM CET

Dear all,

This is the summary of what was discussed in the bioRDF telcon today:

1. Possible overlaps with Scientific Discouse: Anita and Paolo will look
into our the bioRDF provenance of microarray experiments example and try to
identify, with help from the bioRDF group, where the pieces of information
necessary to create the experimental context (e.g. region of the brain where
the samples came from; disease; progression of the disease) are located in
the article. The goal of this is to 1) create a standard that scientists can
use when reporting experimental results (not just from microarrays, possibly
also applicable to next-gen sequencing); and 2) help bioRDF automate the
process of extracting the experimental context from the papers automatically

2. SAGE bionetworks (http://sage.fhcrc.org/downloads/downloads.php) is an
open access integrative framework for scientists working on human disease.
Since SAGE already includes many microarray experiment results (including
TCGA), EricP suggests we start there and provide an RDF framework in which
SAGE members can represent the data.
Eric also suggests we use Bell to describe the experimental results (
http://www.selventa.com/technology/bel-framework)
Lena suggest that, in addition to "increases" and "decreases" expression, we
support "increase by how much" as the results from next-gen sequencing will
be able to provide that information.

3. To truly represent a microarray experiment (and the knowledge derived
from there), we need to be looking into three levels of provenance:
a) the experimental context of the experiment (for microarrays, it may be
easier to extract these from mage-tab; Jim McCusker has a tools to convert
these into RDF); this includes data that is only available on the "methods"
section of the paper

b) the statistical package and set of instructions to create the list of
genes (apparently part of Sage packages); also available on the methods
section of a paper.

c) the actual list of genes that are differentially expressed (part of the
Sage packages; James Malone is also creating an RDF representation of
these); usually available as supplementary material.

4) Plans for the future and an open question: should bioRDF start looking
into next-gen sequencing results and how to represent them using OBI?
(Note: mage-tab now includes a place for reporting next-gen sequencing
results)

Regards,
Lena



On Sun, May 1, 2011 at 9:57 PM, M. Scott Marshall
<mscottmarshall@gmail.com>wrote:

> Here is a reminder for Monday's BioRDF teleconference.
>
> -Scott
>
>
> http://www.w3.org/wiki/HCLSIG_BioRDF_Subgroup/Meetings/2011/05-02_Conference_Call
>
> Conference Details
>
> Date of Call: Monday, April 18, 2011
> Time of Call: 11:00 am Eastern Time, 4 pm UK, 5 pm CET
> Dial-In #: +1.617.761.6200 (Cambridge, MA)
> [Note: limited access to European dial in numbers below]
>
> Dial-In #: +33.4.26.46.79.03 (Nice, France)
> Dial-In #: +44.203.318.0479 (Bristol, UK)
> Participant Access Code: 4257 ("HCLS")
> IRC Channel: irc.w3.org port 6665 channel #HCLS (see W3C IRC page for
> details, or see Web IRC), Quick Start: Use
> http://www.mibbit.com/chat/?server=irc.w3.org:6665&channel=%23hcls for
> IRC access.
> Duration: ~1 hour
> Convener: M. Scott Marshall
> Scribe: TBD
>
> Agenda
> Expression RDF, Progress on the W3C note - All
> AOB
>
>
> -------------------------------------------------------------------------------------------
>
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> this message. Note: there is a clickable link for mibbit below
> that will bring you directly to the right conference channel.
>
>
> -------------------------------------------------------------------------------------------
>
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> ++++
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>
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>
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> --
> M. Scott Marshall, W3C HCLS IG co-chair, http://www.w3.org/blog/hcls
> http://staff.science.uva.nl/~marshall
>
>


-- 
Helena F. Deus
Post-Doctoral Researcher at DERI/NUIG
http://lenadeus.info/