Choosing a use case for an Expert Query Browser

Hi all,

We are interested in building an "expert" query browser to answer
queries similar to the ones outlined in [1].

We thought the following use case listed in the wiki would be a good
one to start with:

"Fundamental questions will be answered by the ontology at this stage
by sourcing the data sets listed below simultaneously or in a specific
order.
A. What are the clinically recommended agents NICE
B. What products are available to prescribe, and which are legally
indicated for disease AD [DOID: 10652]? [Physicians Desk Reference]
C. What is the SNP verdict? These agents are sourced with
pharmacogenomics database Pharmacogenetics Research Network (PGRN) to
determine (Data source: PharmaGKB, Michel's DB (depression))
Will they be efficacious? Receptor positive disease?
Will they be harmful? Toxic metabolites? Available CYP 450 or
acetylator status? (Data source: Drugbank, Dailymed?, SIDER?)
D. Are the resulting pharmaceutical agents covered by the patient’s
specific insurance? (In real time). Are the preceding predictive
genetic SNP tests covered by the patient’s insurance company? These
may be recommended and indicated prior to treatment as in HIV
medication ABACAVIR.(PGRN, PDR, NICE, Medicare, Blue Cross Blue
Shield)
The Physician [NCI Thesaurus: Physician] checks with pharmacist, or
consults drug information literature to avoid potential drug
interactions"

We were wondering about the availability of the data sources mentioned
in this particular use case: has somebody exported those to RDF? Or
are there any efforts underway?

Or else, is there any other use case for which we can use the relevant
ontologies which already has data in RDF?

Also, we are wondering what specific use cases would be most relevant
to the community at the moment?

[1] http://esw.w3.org/topic/HCLSIG/PharmaOntology/UseCases

Thanks,
Oshani and Rachel

Received on Saturday, 31 October 2009 01:29:09 UTC