- From: Eric Jain <Eric.Jain@isb-sib.ch>
- Date: Thu, 19 Jul 2007 17:56:57 +0200
- To: Darren Natale <dan5@georgetown.edu>
- CC: Alan Ruttenberg <alanruttenberg@gmail.com>, Chris Mungall <cjm@fruitfly.org>, Bijan Parsia <bparsia@cs.man.ac.uk>, public-semweb-lifesci hcls <public-semweb-lifesci@w3.org>
Darren Natale wrote: > We don't yet have formal definitions for many of the classes and > relations (the effort only began in earnest a few months ago). But, > basically, there is a distinction made between the full-length (in terms > of amino acid sequence) protein and the sub-length parts of proteins > (commonly called domains by protein scientists, unfortunately). The > term "whole protein" is somewhat of a placeholder; it is used to signify > the evolutionary classes (families) of full-length proteins as opposed > to the evolutionary classes of domains. Sequence form is again a > placeholder term used to denote the initial translation product from an > mRNA, which itself might be based on a "normal" gene or a mutant > thereof, or which might be one of several possible alternatively spliced > transcripts from the normal or mutant gene. The cleaved or modified > product is a further breakdown of those initial translation products, > and allows one to distinguish between a phosphorylated version of a > protein and the non-phosphorylated version (as an example). The need > for the latter derives from the fact that the two versions might have > different functions. Thanks! And what is a "protein", in this scheme? :-)
Received on Thursday, 19 July 2007 15:57:10 UTC