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RE: HCLS chartering/next steps Thur 16 June

From: Michael Miller <Michael.Miller@systemsbiology.org>
Date: Thu, 16 Jun 2011 08:08:58 -0700
Message-ID: <e3952b79afb5f7e0a516c13899e8cf41@mail.gmail.com>
To: Helena Deus <helenadeus@gmail.com>, "Eric Prud'hommeaux" <eric@w3.org>
Cc: public-semweb-lifesci@w3.org
hi all,

regrets also and +1 to both of lena's points



*From:* public-semweb-lifesci-request@w3.org [mailto:
public-semweb-lifesci-request@w3.org] *On Behalf Of *Helena Deus
*Sent:* Thursday, June 16, 2011 7:56 AM
*To:* Eric Prud'hommeaux
*Cc:* public-semweb-lifesci@w3.org
*Subject:* Re: HCLS chartering/next steps Thur 16 June

Regrets, I cannot attend the call :-(

A few points:

1. Suggest to change in the High Level Use cases

- *Structured protocols* and experimental results

I think we need to elaborate at least one of the use cases and describe them
as a workflow (e.g. user needs to find about a pathway where two proteins
are involved; user goes to uniprot to find the two proteins, finds the
identified in kegg pathways and interactome, searches those databases, finds
a list of other potential interacting proteins; uploads the data in string
db, etc). This will help identify the gaps and help devise the deliverables
around it.

As it is, the use cases are more topics for exploring use cases.

2. We've been brainstorming about the mission statement here at DERI and
here is what we came up with (based on the proposal by Tim Clark):

The mission of the W3C HCLS IG is to exploit interdisciplinary, semantic web
research so that stakeholders in health care and life sciences can
collaborate and interoperate on a global scale.

We enable this mission by actively adopting Web interoperability standards
applicable to HCLS, and providing feedback to the standards development
groups within the W3C based on our experiences. Our program is based on
real-life requirements for the Web-based support of scientific and clinical
activities, and a vision of 21st century research in biology and medicine.
The evolving "web of data" is a critical component of this vision.

The HCLS-IG actively supports the in-depth, practical involvement of
multidisciplinary researchers in basic, clinical, and translational science
in the application and development of these standards. Our activities
include requirements and scenario formulation, tutorials, demonstrations and
ontology development, hosting workshops, and dissemination in peer-reviewed
journals and conferences.

3. We have also came up with a number of activities that may be interesting
to explore beyond what is already in the charter

Health Care domains

   - Improved Diagnosis: Enable diagnostic decisions based on previous
   evidence and aggregation of data from multiple electronic health record
   system (EHR)
   - Clinical Information Exchange: develop (semi-)automated ontology
   building and alignment methods/tools for non-ontological healthcare
   resources. Clinical information consists of different information parts
   (e.g., medical history, lab observation) of a comprehensive patient record.
   The clinical information uses several vocabularies and constraints to
   describe their contents. Each of these vocabularies either described and
   controlled by the standardisation committees or by local users. The use of
   semantics for successful Clinical Information Exchange can reach to
   full-potential by adopting domain specific methodologies and tool sets.
   - Patient-Centric Care: develop context-aware and modular Semantic Web
   framework. Patient's clinical information spans across different sites,
   treatment occasions, diseases, medical situations (e.g., routine,
   accidents), etc. It is important to arrange them in information modules and
   integration should be centered according to point-of-care, that is, only
   those information pieces should be combined or excluded that are appropriate
   for any treatment situation.

Life Sciences Domains

   - Systems Biology: integration of multiple "omics" sciences
   - Functional and Pathway Analysis of Expression Data: analysis of gene
   expression results by categorizing results in terms of gene sets (there is
   very little work going on in this area and a VERY big need. I know work
   going on in the Netherlands where this area is under development.)
   - Structure Bioinformatics/Chemoinformatics: integration of information
   regarding chemical components (Egon has done most of the work in this
   domain, time we help him a bit?)



On Thu, Jun 16, 2011 at 1:58 AM, Eric Prud'hommeaux <eric@w3.org> wrote:

Hi again again. Since last we met, I pushed some documents around and
piled some words into others. The High Level Use Cases (AKA elevator
pitches) doc is now on the wiki:
The on-deck charter remains where it was:
Scott wrote up a brag sheet to show what we accomplished in this charter:
and I wrote a narrative version catering to pharmas:
Join me tomorrow at the usual time (11.00 EDT, 15.00Z)?

* Eric Prud'hommeaux <eric@w3.org> [2011-06-01 22:06-0400]
> Hi all again. Last week we had some good idea exchange about what we
> should put into the next HCLSIG charter, i.e. what we tell the world
> we are doing. We agreed that we weren't done and that we'd like to
> meet in one week. I invite all to meet tomorrow, Thursday 2 June.
> Details at the bottom of the message.
> * Eric Prud'hommeaux <eric@w3.org> [2011-05-23 23:04-0400]
> > Hi all, as some of you reallize, the charter ends at the end of this
> > month. I've been polling around to see what alternative formulations
> > would give us the most resources and impact. In the process, I wrote
> > up some of our high-level use cases (elevator speeches) to help us
> > approach the relevant parties in pharmas, health services and
> > research: <http://www.w3.org/2011/05/HCLSIGUseCases>.
> >
> > I'd like to discuss the landscape and potential strategies with the
> > community. I'd particularly like to invite those who have been active
> > or see themselves as being active in the next incarnation of the group.
> > We'll discuss the current, fairly conservative draft charter
> > <http://www.w3.org/2011/05/HCLSIGCharter-proposal>, as well as ways to
> > optimize both its message and the paths for dissemination. An example
> > of a messaging alternative would be to characterize the HCLS IG work
> > in terms of e.g. overarching translational medicine use cases:
> > "
> >   The W3C Semantic Web in Health Care and Life Sciences Interest Group
> >   focuses on translational medicine use cases. The group will continue
> >   the aggregation of cutting edge and traditional scientific knowledge
> >   to meet use cases for researchers, care givers, patients and
> >   regulatory agencies. Due to the scope and diversity of expertise
> >   required to meet translational needs, the HCLS IG work is broken
> >   down into discrete task forces focused on particular data
> >   acquisition, modeling and integration requirements:
> >
> >   Terminology - identifying and integrating identifiers for biological
> >   processes, gross anatomy and medical procedures to promote
> >   unification of domain data.
> >
> >   LODD - curation of compounds, clinical trials and outcomes.
> >
> >   BioRDF - modeling of biological processes and actors.
> >
> >   Scientific Discourse - representation and tracking of the changing
> >   landscape of scientific knowledge and the driving theora and
> >   experiments.
> >
> >   Translational Medicine - the oversight and high-level ontology that
> >   connects these disciplines together in order to meet immediate and
> >   long term needs from pharma, health care and other vested parties.
> > "
> > . Perhaps you all have some other ideas about how to tell a story
> > about our work which will serve to both draw people to our work and
> > our products and to help already interested parties find the task
> > forces which interest them. I of course want to draw an optimal
> > balance between doing work which motivates the participants and
> > focusing on tasks which will accelerate education and adoption by
> > important organizations.
> >
> > I'm sure you are all aware of my preference for technical work, but I
> > feel that this outreach can make us all ultimately more effective. I
> > will use the Thursday 26 May HCLS slot (11:00 EDT) to reach out to the
> > current HCLS IG community, and whomever else you folks elect to bring
> > along. Of course, I'll reserve extra teleconference slots, but please
> > RSVP to me privately so I can make a guess at how many ports to
> > reserve. Also, please provide what feedback you can before the
> > conference. Anything we take care of before will make the meeting more
> > efficient.
> >
> > Conference Details
> >
> > Date of Call:xThursday,xMayx26,x2011x
>                 Thursday, June 2, 2011
> > Time of Call: 11:00 am Eastern Time, 4 pm UK, 5 pm CET
> > Dial-In #: +1.617.761.6200 (Cambridge, MA)
> > [Note: limited access to European dial in numbers below]
> > Dial-In #: + (Nice, France)
> > Dial-In #: +44.203.318.0479 (Bristol, UK)
> > Participant Access Code: 4257 ("HCLS")
> > IRC Channel: irc.w3.org port 6665 channel #HCLS (see W3C IRC page for
> > details, or see Web IRC), Quick Start: Use
> > http://www.mibbit.com/chat/?server=irc.w3.org:6665&channel=%23hcls for
> > IRC access.
> > Duration: ~1 hour
> > Convener: Eric Prud'hommeaux
> > Scribe: TBD
> >
> > HCLS IG charter/strategy discussion
> > --
> > -ericP
> --
> -ericP


Helena F. Deus

Post-Doctoral Researcher at DERI/NUIG

Received on Thursday, 16 June 2011 15:09:37 UTC

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