- From: Eric Jain <Eric.Jain@isb-sib.ch>
- Date: Thu, 19 Jul 2007 17:05:55 +0200
- To: Darren Natale <dan5@georgetown.edu>
- CC: Alan Ruttenberg <alanruttenberg@gmail.com>, Chris Mungall <cjm@fruitfly.org>, Bijan Parsia <bparsia@cs.man.ac.uk>, public-semweb-lifesci hcls <public-semweb-lifesci@w3.org>
Darren Natale wrote: > We recently began a new Protein Ontology (PRO) effort geared precisely > toward the formal definition of the "smaller entities" referred to by > Alan. By "we" I mean the PRO Consortium, comprising the PIs Cathy Wu of > PIR (which is also a member organization of the UniProt Consortium), > Barry Smith of SUNY Buffalo, and Judy Blake of Jackson Labs. PRO is > being developed within the framework of the OBO Foundry, and aims to > specify protein entities at the level mentioned by Chris (accounting for > splice variation and post-translational modification and cleavage). > Where appropriate, PRO will indeed make reference to both other > ontologies and to UniProt Knowledgebase (UniProtKB) records. > Furthermore, we are also undertaking the "wildly ambitious" job of > representing broader, more-inclusive classes of similar proteins based > on evolutionary relatedness. > > A further description of PRO (with examples and link to a paper) can be > found at http://pir.georgetown.edu/pro This will no doubt be interesting to quite a few people here! For the sake of this discussion, could you elaborate a bit more on how the different concepts in PRO are defined, i.e. what is a "protein", "whole protein", "sequence form" and "cleaved and/or modified product"?
Received on Thursday, 19 July 2007 15:06:21 UTC