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Clinical part of HCLS demo

From: Eric Neumann <eneumann@teranode.com>
Date: Sat, 17 Feb 2007 16:51:00 -0500
Message-ID: <A3970D83EC72E84B8D2C2400CD6F0B9FE9B2C3@MI8NYCMAIL16.Mi8.com>
To: "Alan Ruttenberg" <alanr@mumble.net>
cc: public-hcls-dse@w3.org
Alan,

Here is a draft for a possible clinical angle to the HCLS demo...

1. Extend PD/AD demo to include clinical study data from patients, using DSE's draft RDF model based on CDISC's SDTM standard: 
http://esw.w3.org/topic/HCLSIG/Drug_Safety_and_Efficacy/SDTM/Example_N3#Clinical_Data

2. Compile patient data for either:
    a. disease progression - base on symptomatic terminology such as EOAD or MCI for AD, and tremor, hyperkinetic dysarthia, or bradykinesia for PD 
or b. new drug trial - dosing, symptomatic response patterns over time + any observed adverse events (AE)

3. If drug trial, then links to PubChem drug information would be useful: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pccompound
  - for AD:  Cognex, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2723754 (images- http://pubchem.ncbi.nlm.nih.gov/image/structurefly.cgi?cid=2723754)
  - for PD: Cogentin, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441352
     or Piribedil, http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=198284

4. Use either set of data to show trends using a simple graph visualization (generic table to graph tool?)


-Eric
Received on Saturday, 17 February 2007 21:51:19 GMT

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