Subcellular Anatomy Ontology (SAO) Individuals
type: Ontology
subject: Individuals described using the ontology for the subcellular anatomy of the nervous system
curation status: uncurated
creator: Maryann Martone, Lisa Fong, Stephen D. Larson, Sarah M. Maynard
date: August 21, 2007
version info: Version 1.2.5
imports: http://www.ifomis.org/bfo/1.0
imports: SAO.owl

Ubiquitin 03
type: sao9074887086
contributor: Sarah M. Maynard
sao1939689633: Lewy Body 05
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A

Lewy Body 05
type: sao4933778419
sao138767806: Nerve Cell 01
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
sao152994059: Ubiquitin 03
sao152994059: Alpha-Synuclein Protein 13
comment: Lewy Body in a nerve cell in the substantia nigra double-stained for alpha-Synuclein (antibody PER2) and ubiquitin; human/Parkinson's Disease
contributor: Sarah M. Maynard

Nerve Cell 01
type: sao1224657022
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
contributor: Sarah M. Maynard
sao1623809261: Lewy Body 05
comment: located in Substantia Nigra

Alpha-Synuclein Protein 13
type: sao5651809446
sao1939689633: Lewy Body 05
comment: stained with PER2
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
contributor: Sarah M. Maynard

Cortical Lewy Body 02
type: sao4040591221
sao152994059: Alpha-Synuclein Protein 25
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1A
contributor: Sarah M. Maynard
comment: need to say in pigmented neurons of substantia nigra
comment: brainstem Lewy body in pigmented neurons of substantia nigra stains for alpha-synuclein; human/dementia with Lewy bodies

Alpha-Synuclein Protein 25
type: sao5651809446
sao1939689633: Cortical Lewy Body 02
contributor: Sarah M. Maynard
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1A

Alpha-Synuclein Protein 04
type: sao5651809446
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters
comment: correct to say is_Component of Neuron? (alpha-synuclein is accumulated in Neurons)
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]
sao2103390115: Accumulated 02
sao138767806: Neuron 01

Accumulated 02
type: sao4531544124
contributor: Sarah M. Maynard
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters

Neuron 01
type: sao1417703748
contributor: Sarah M. Maynard
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]
sao1623809261: Alpha-Synuclein Protein 04

Lewy Neurite 03
type: sao601362597
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 08
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2B
comment: alpha-Synuclein positive Lewy neurite in substantia nigra stained with PER2; human/dementia with Lewy bodies

Alpha-Synuclein Protein 08
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2B
contributor: Sarah M. Maynard
sao1939689633: Lewy Neurite 03
comment: stained with PER2

Ubiquitin 08
type: sao9074887086
sao1939689633: Lewy Neurite 10
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G
contributor: Sarah M. Maynard

Lewy Neurite 10
type: sao601362597
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G
sao152994059: Ubiquitin 08
sao152994059: Alpha-Synuclein Protein 24
comment: Intraneuritic Lewy neurite double stained for alpha-synuclein (antibody PER1) in cingulate cortex; human/dementia with Lewy bodies
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 24
type: sao5651809446
comment: stained with PER1
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G
contributor: Sarah M. Maynard
sao1939689633: Lewy Neurite 10

Fibril 02
type: sao5051906853
source: Lippa et al. 2007. DLB and PDD boundry issues: Diagnosis, treatment, molecular pathology, and biomarkers. Neurology 68:812-819.

Lewy Body 12
type: sao4933778419
sao138767806: Substantia Nigra Dopaminergic Cell 05
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 26
comment: Lewy body stains for alpha-synuclein in cytoplasm of dopaminergic substantia nigra neurons; human/dementia with Lewy bodies
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1D

Substantia Nigra Dopaminergic Cell 05
type: sao34994437
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1D
comment: in cytoplasm of cell
sao1623809261: Lewy Body 12
sao1863785805: false
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 26
type: sao5651809446
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1D
sao1939689633: Lewy Body 12
contributor: Sarah M. Maynard

Interleukin-1 02
type: sao950082944
sao1939689633: Microglia 01
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.
comment: it is overexpressed
comment: Alzheimer's disease patient

Microglia 01
type: sao789292116
sao2103390115: Activated 15
sao138767806: Neuritic Plaque 01
sao152994059: Interleukin-1 02
comment: Alzheimer's disease patient
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.
contributor: Sarah M. Maynard

Activated 15
type: sao5413665309
comment: Alzheimer's disease patient
contributor: Sarah M. Maynard
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Neuritic Plaque 01
type: sao9515821206
comment: Alzheimer's disease patient
contributor: Sarah M. Maynard
sao152994059: Beta-Amyloid 01
sao1623809261: Microglia 01
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Beta-Amyloid 01
type: sao471310941
comment: Alzheimer's disease patient
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.
contributor: Sarah M. Maynard
sao1939689633: Neuritic Plaque 01

Alpha-Synuclein Protein 01
type: sao5651809446
comment: Lewy Neurites stain for alpha-synuclein.
sao1939689633: Lewy Neurite 01
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.

Lewy Neurite 01
type: sao601362597
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.
sao152994059: Alpha-Synuclein Protein 01

Lewy Body 03
type: sao4933778419
sao138767806: Substantia Nigra Dopaminergic Cell 02
comment: alpha-Synuclein positive Lewy bodies in substantia nigra stained with PER1; human/dementia with Lewy bodies
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. figure 2A
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 11

Substantia Nigra Dopaminergic Cell 02
type: sao34994437
sao1863785805: false
sao1623809261: Lewy Body 03
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2A
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 11
type: sao5651809446
comment: stained with PER1
sao1939689633: Lewy Body 03
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2A

Alpha-Synuclein Protein 14
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
comment: stained with PER2
sao1939689633: Lewy Body 06
contributor: Sarah M. Maynard

Lewy Body 06
type: sao4933778419
sao152994059: Alpha-Synuclein Protein 14
comment: Lewy body in a nerve cell in the substantia nigra stianed only for alpha-synuclein (antibody PER2); human/Parkinson's Disease
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
contributor: Sarah M. Maynard
sao138767806: Nerve Cell 02

Nerve Cell 02
type: sao1224657022
sao1623809261: Lewy Body 06
comment: located in substantia nigra
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3A
contributor: Sarah M. Maynard

Cortical Lewy Body 03
type: sao4040591221
contributor: Sarah M. Maynard
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1B
comment: Lewy body in cingulate cortex (neocortex) stained for alpha-synuclein; human/dementia with Lewy bodies

Nerve Cell 03
type: sao1224657022
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
contributor: Sarah M. Maynard
sao1623809261: Lewy Body 07
comment: located in the Substantia Nigra

Lewy Body 07
type: sao4933778419
sao1434436507: Corona 04
comment: Lewy Body double-stained for alpha-Synuclein (antiboty PER2) and ubiquitin in a nerve cell in the substantia nigra. The halo of the Lewy body is strongly immoreactive for alpha-synuclein. (3 Lewy Bodies in this figure)
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
sao152994059: Alpha-Synuclein Protein 15
sao152994059: Ubiquitin 04
sao138767806: Nerve Cell 03
sao1434436507: Core 03
contributor: Sarah M. Maynard

Corona 04
type: sao5764355747
contributor: Sarah M. Maynard
sao1239937685: Lewy Body 07
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
sao152994059: Alpha-Synuclein Protein 16

Alpha-Synuclein Protein 16
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
sao1939689633: Corona 04
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 15
type: sao5651809446
comment: stained with PER2
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
contributor: Sarah M. Maynard
sao1939689633: Lewy Body 07

Ubiquitin 04
type: sao9074887086
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
sao1939689633: Lewy Body 07

Core 03
type: sao6587439252
sao1239937685: Lewy Body 07
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3B
contributor: Sarah M. Maynard

sao2108323256 61
type: sao2108323256
source: Masliah et al. 2000. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 18. Vol 287(5456):1265-1269.

example schwann cell compact myelin 1
type: sao-1123256993
sao4245285112: example juxtaparanode 1
sao4245285112: example internode 1
sao1239937685: example schwann cell 1

example juxtaparanode 1
type: sao758620702
sao7022761014: example paranode 1
sao7022761014: example internode 1
sao9371595441: example schwann cell compact myelin 1
sao9371595441: example juxtaparnode axon 1

example paranode 1
type: sao-234066064
sao9371595441: example schwann cell paranodal termination 1
sao9371595441: example paranode axon 1
sao7022761014: example juxtaparanode 1
sao7022761014: example node of ranvier 1

example schwann cell paranodal termination 1
type: sao-1067215520
sao1239937685: example schwann cell 1
sao4245285112: example paranode 1

example schwann cell 1
type: sao408819766
sao1434436507: example schwann cell paranodal termination 1
sao1434436507: example schwann cell compact myelin 1

example paranode axon 1
type: sao936144858
sao152994059: example potassium channel
sao4245285112: example paranode 1
sao1239937685: example axon 1
sao1896217670: example juxtaparnode axon 1

example potassium channel
type: sao666200564
sao1939689633: example paranode axon 1

example axon 1
type: sao1770195789
sao1434436507: example paranode axon 1
sao1434436507: example internode axon 1
sao1434436507: example juxtaparnode axon 1
sao1434436507: example node of ranvier axon 1

example internode axon 1
type: sao830092290
sao4245285112: example internode 1
sao1239937685: example axon 1

example internode 1
type: sao-206157942
sao9371595441: example schwann cell compact myelin 1
sao9371595441: example internode axon 1
sao7022761014: example juxtaparanode 1

example juxtaparnode axon 1
type: sao1191319089
sao4245285112: example juxtaparanode 1
sao1896217670: example paranode axon 1
sao1239937685: example axon 1

example node of ranvier axon 1
type: sao-188049490
sao1239937685: example axon 1
sao4245285112: example node of ranvier 1
sao152994059: example voltage gated sodium channel 1

example node of ranvier 1
type: sao571652273
sao9371595441: example node of ranvier axon 1
sao9371595441: example peripheral astrocyte process 1
sao7022761014: example paranode 1

example peripheral astrocyte process 1
type: sao1573004591
sao1239937685: example astrocyte 1
sao4245285112: example node of ranvier 1

example astrocyte 1
type: sao1394521419
sao1434436507: example peripheral astrocyte process 1

example voltage gated sodium channel 1
type: sao785001660
sao1939689633: example node of ranvier axon 1

Lewy Body 08
type: sao4933778419
sao138767806: Nerve Cell 04
comment: Lewy Body in nerve cell in the substantia nigra double-stained for alpha-synuclein (antibody PER1) and ubiquitin; human/Parkinson's Disease
contributor: Sarah M. Maynard
sao152994059: Ubiquitin 05
sao152994059: Alpha-Synuclein Protein 17
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C

Nerve Cell 04
type: sao1224657022
contributor: Sarah M. Maynard
sao1623809261: Lewy Body 08
comment: located in the Substantia Nigra
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C

Ubiquitin 05
type: sao9074887086
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C
sao1939689633: Lewy Body 08
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 17
type: sao5651809446
contributor: Sarah M. Maynard
comment: stained with PER1
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C
sao1939689633: Lewy Body 08

Aggregated 01
type: sao3710738764
contributor: Sarah M. Maynard
source: Lippa et al. 2007. DLB and PDD boundry issues: Diagnosis, treatment, molecular pathology, and biomarkers. Neurology 68:812-819.

Lewy Neurite 08
type: sao601362597
contributor: Sarah M. Maynard
comment: Lewy neurite stained for alpha-synuclein by using antibody PER1; human/Parkinson's Disease
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3E
sao152994059: Alpha-Synuclein Protein 21

Alpha-Synuclein Protein 21
type: sao5651809446
comment: stained with PER1
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3E
contributor: Sarah M. Maynard
sao1939689633: Lewy Neurite 08

Lewy Neurite 07
type: sao601362597
contributor: Sarah M. Maynard
sao138767806: Substantia Nigra Dopaminergic Cell 03
comment: Lewy neurite in substantia nigra double-stained for alpha-synuclein and ubiqutin; human/Parkinson's Disease
sao152994059: Ubiquitin 06
sao152994059: Alpha-Synuclein Protein 19
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3D

Substantia Nigra Dopaminergic Cell 03
type: sao34994437
sao1863785805: false
sao1623809261: Lewy Neurite 07
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3D

Ubiquitin 06
type: sao9074887086
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3D
sao1939689633: Lewy Neurite 07

Alpha-Synuclein Protein 19
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3D
sao1939689633: Lewy Neurite 07
contributor: Sarah M. Maynard

Activated 9
type: sao5413665309
comment: Alzheimer's disease patient
contributor: Sarah M. Maynard
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Alpha-Synuclein Fibril 01
type: sao7474011676
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 4(A and B)
contributor: Sarah M. Maynard
sao2103390115: Aggregated 03
comment: Small clumps of alpha-synuclein filaments in cingulated cortex; human/dementia with Lewy bodies

Aggregated 03
type: sao3710738764
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 4(A and B)

Alpha-Synuclein Protein 12
type: sao5651809446
sao1939689633: Lewy Body 04
contributor: Sarah M. Maynard
comment: stained with PER2
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2E

Lewy Body 04
type: sao4933778419
sao152994059: Ubiquitin 01
sao152994059: Alpha-Synuclein Protein 12
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2E
comment: Lewy Body is intraneuritic
sao138767806: Substantia Nigra Dopaminergic Cell 01
sao138767806: Lewy Neurite 06

Ubiquitin 01
type: sao9074887086
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2E
contributor: Sarah M. Maynard
comment: stained with PER2
sao1939689633: Lewy Body 04

Substantia Nigra Dopaminergic Cell 01
type: sao34994437
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2E
sao1863785805: false
sao1623809261: Lewy Body 04
contributor: Sarah M. Maynard

Lewy Neurite 06
type: sao601362597
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2E
contributor: Sarah M. Maynard
comment: alpha-Synuclein positive intraneuritic Lewy Body in a Lewy Neurite in the substantia nifra stained with PER2; human/dementia with Lewy bodies
sao1623809261: Lewy Body 04

Core 02
type: sao6587439252
comment: The alpha-synuclein is stained in the core of Lewy Body.
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.
sao1239937685: Lewy Body 02
sao152994059: Alpha-Synuclein Protein 05
contributor: Sarah M. Maynard

Lewy Body 02
type: sao4933778419
sao1434436507: Core 02
sao1434436507: Corona 03
contributor: Sarah M. Maynard
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.

Corona 03
type: sao5764355747
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.
sao1239937685: Lewy Body 02
comment: The corona of the Lewy Body stains for alpha-synuclein.
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 07

Alpha-Synuclein Protein 07
type: sao5651809446
sao1939689633: Corona 03
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 05
type: sao5651809446
source: Tofaris et al. 2005. Alpha-Synuclein Dysfunction in Lewy Body Diseases. Vol 20 Suppl. 12 pp S37-S44.
sao1939689633: Core 02
contributor: Sarah M. Maynard

Nerve Cell 06
type: sao1224657022
source: Vicker JC et al. 2003. Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease. Brain Research 971:135-137. Figure 1
sao1623809261: Neurofibrillary Tangle 01
contributor: Sarah M. Maynard

Neurofibrillary Tangle 01
type: sao2409833926
comment: Neurofibrillary trangle with tau and MAP2, located in nerve cell body in neocortex
contributor: Sarah M. Maynard
source: Vicker JC et al. 2003. Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease. Brain Research 971:135-137. Figure 1
sao138767806: Nerve Cell 06
sao152994059: MAP2 01
sao152994059: Tau 02

MAP2 01
type: sao1707694834
contributor: Sarah M. Maynard
sao1939689633: Neurofibrillary Tangle 01
source: Vicker JC et al. 2003. Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease. Brain Research 971:135-137. Figure 1

Tau 02
type: sao1077731745
source: Vicker JC et al. 2003. Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease. Brain Research 971:135-137. Figure 1
contributor: Sarah M. Maynard
sao1939689633: Neurofibrillary Tangle 01

Interleukin-1 01
type: sao950082944
sao1939689633: Microglia 03
comment: Alzheimer's disease patient
comment: it is being overexpressed
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Microglia 03
type: sao789292116
sao152994059: Interleukin-1 01
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.
sao2103390115: Activated 9
comment: Alzheimer's disease patient
sao138767806: Amyloid Aggregate 7

Amyloid Aggregate 7
type: sao4785563283
sao1623809261: Microglia 03
comment: specifically: "amyloid deposit" that is diffuse
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Autophagosome 9
type: sao8663416959
comment: would it be correct to say Autophagosome has_Component Mitochondrion if instance is "Mitochondria found in Autophagosomes" ?
comment: specifics: axotomy of superior cervical ganglion (SCG) neurons in adult rats
source: Rubinsztein DC et al. 2005. Autophagy and Its Possible roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22.
sao1623809261: sao1860313010 11

sao1860313010 11
type: sao1860313010
comment: specifics: axotomy of superior cervical ganglion (SCG) neurons in adult rats
sao138767806: Autophagosome 9
source: Rubinsztein DC et al. 2005. Autophagy and Its Possible roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22.

Alpha-Synuclein Protein 10
type: sao5651809446
comment: stained with PER2
sao1939689633: Lewy Neurite 05
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2D
contributor: Sarah M. Maynard

Lewy Neurite 05
type: sao601362597
comment: alpha-Synuclein positive Lewy neurite in hippocampus stained with antibody PER1; human/dementia with Lewy bodies
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2D
sao152994059: Alpha-Synuclein Protein 10
sao138767806: Hippocampal Pyramidal Neuron 02

Hippocampal Pyramidal Neuron 02
type: sao131261273
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2D
contributor: Sarah M. Maynard
sao1623809261: Lewy Neurite 05

Alpha-Synuclein Protein 28
type: sao5651809446
sao1939689633: Lewy Neurite 12
contributor: Sarah M. Maynard
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1L

Lewy Neurite 12
type: sao601362597
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1L
contributor: Sarah M. Maynard
comment: alpha-synuclein positive abnormal neurites in temporal neocortex; human/dementia with Lewy bodies
sao152994059: Alpha-Synuclein Protein 28

Alpha-Synuclein Protein 02
type: sao5651809446
sao1939689633: Neurofilament 01
contributor: Sarah M. Maynard
source: McKeith I. 2002. Dementia with Lewy bodies. British Journal of Psychiatry 180:144-147.

Neurofilament 01
type: sao1316272517
contributor: Sarah M. Maynard
sao2103390115: Phosphorylated 01
sao152994059: Alpha-Synuclein Protein 02
sao152994059: Ubiquitin 02
sao138767806: Lewy Body 01
source: McKeith I. 2002. Dementia with Lewy bodies. British Journal of Psychiatry 180:144-147.

Phosphorylated 01
type: sao4985712724
contributor: Sarah M. Maynard
comment: Abnormally phosphorylated.
source: McKeith I. 2002. Dementia with Lewy bodies. British Journal of Psychiatry 180:144-147.

Ubiquitin 02
type: sao9074887086
sao1939689633: Neurofilament 01
source: McKeith I. 2002. Dementia with Lewy bodies. British Journal of Psychiatry 180:144-147.
contributor: Sarah M. Maynard

Lewy Body 01
type: sao4933778419
sao1623809261: Neurofilament 01
contributor: Sarah M. Maynard
source: McKeith I. 2002. Dementia with Lewy bodies. British Journal of Psychiatry 180:144-147.

Neuritic Plaque 02
type: sao9515821206
source: Forno LS. Neuropathologic Features of Parkinson's, Huntington's, and Alzheimer's Diseases. Annals New York Academy of Sciences
comment: The neuritic plaque has an amyloid core stained with Luxol fast blue-Bielschowsky silver stain

Lewy Body 11
type: sao4933778419
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G
comment: Intraneuronal Lewy Body double stained for alpha-synuclein (antibody PER1) and ubiquitin in cingulate cortex; human/dementia with Lewy bodies
contributor: Sarah M. Maynard
sao152994059: Ubiquitin 07
sao152994059: Alpha-Synuclein Protein 23

Ubiquitin 07
type: sao9074887086
contributor: Sarah M. Maynard
sao1939689633: Lewy Body 11
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G

Alpha-Synuclein Protein 23
type: sao5651809446
contributor: Sarah M. Maynard
comment: stained with PER1
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3G
sao1939689633: Lewy Body 11

Core 01
type: sao6587439252
source: Trojanowski JQ, Lee VM. 1994. Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann NY Acad Sci 747:92-109
sao1623809261: FIlament 01
comment: Core has_Component filaments (a matted meshwork of filaments)

FIlament 01
type: sao7561423738
source: Trojanowski JQ, Lee VM. 1994. Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann NY Acad Sci 747:92-109
sao138767806: Core 01

Alpha-Synuclein Protein 18
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C
comment: stained with PER1
contributor: Sarah M. Maynard
sao1939689633: Lewy Body 10

Lewy Body 10
type: sao4933778419
sao152994059: Alpha-Synuclein Protein 18
comment: Lewy Body in nerve cell in substantia nigra stained for alpha-synuclein (antibody PER1); human/Parkinson's Disease
sao138767806: Nerve Cell 05
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C
contributor: Sarah M. Maynard

Nerve Cell 05
type: sao1224657022
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3C
comment: located in the substantia nigra
sao1623809261: Lewy Body 10

Lewy Body 09
type: sao4933778419
contributor: Sarah M. Maynard
comment: alpha-Synuclein positive Lewy body in substantia nigra stained with PER2; human/dementia with Lewy bodies
sao138767806: Substantia Nigra Dopaminergic Cell 04
sao152994059: Alpha-Synuclein Protein 20
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2B

Substantia Nigra Dopaminergic Cell 04
type: sao34994437
sao1863785805: false
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2B
sao1623809261: Lewy Body 09
contributor: Sarah M. Maynard

Alpha-Synuclein Protein 20
type: sao5651809446
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2B
contributor: Sarah M. Maynard
comment: stained with PER2
sao1939689633: Lewy Body 09

Lewy Neurite 09
type: sao601362597
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3F
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 22
comment: Lewy neurite stained for alpha-synuclein by using antibody PER2

Alpha-Synuclein Protein 22
type: sao5651809446
contributor: Sarah M. Maynard
sao1939689633: Lewy Neurite 09
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 3F
comment: stained with PER2

Alpha-Synuclein Protein 29
type: sao5651809446
contributor: Sarah M. Maynard
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1M
sao1939689633: Lewy Neurite 13

Lewy Neurite 13
type: sao601362597
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1M
sao152994059: Alpha-Synuclein Protein 29
comment: Lewy neurites positive for alpha-Synuclein; human/dementia with Lewy bodies
contributor: Sarah M. Maynard

Neuropil Thread 01
type: sao9537723288
sao152994059: Tau 01
comment: tau-positive neuropil threads in CA2/3 region of hippocampus
contributor: Sarah M. Maynard
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1M

Tau 01
type: sao1077731745
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1M
contributor: Sarah M. Maynard
sao1939689633: Neuropil Thread 01

Aggregated 02
type: sao3710738764
contributor: Sarah M. Maynard
source: Lippa et al. 2007. DLB and PDD boundry issues: Diagnosis, treatment, molecular pathology, and biomarkers. Neurology 68:812-819.

Oligodendrocyte 01
type: sao844118448
sao1623809261: Alpha-Synuclein Protein 03
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]

Alpha-Synuclein Protein 03
type: sao5651809446
sao138767806: Oligodendrocyte 01
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters
comment: correct to say is_Component of Oligodendrocyte? (alpha-synuclein is accumulated in Oligodendrocytes)
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]
sao2103390115: Accumulated 01

Accumulated 01
type: sao4531544124
contributor: Sarah M. Maynard
source: Rockenstein et al. Differential Neuropathological Alteratins in Transgenic Mice Expressing alpha-synuclein From the Platetelet-derived Growth Factor and Thy-1 Promoters [citing: Wakabayashi et al., 1998; Spillantini et al., 1998]
comment: Transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and thy-1 promoters

Alpha-Synuclein Protein 27
type: sao5651809446
contributor: Sarah M. Maynard
sao1939689633: Cortical Lewy Body 04
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1L

Cortical Lewy Body 04
type: sao4040591221
comment: alpha-synuclein positive Lewy body in temporal neocortex
contributor: Sarah M. Maynard
sao152994059: Alpha-Synuclein Protein 27
source: Baba M et al. 1998. Aggregation of alpha-Synuclein in Lewy Bodies of Sporadic Parkinson's Disease and Dementia with Lewy Bodies. American Journal of Patholofy 152(4):879-884. Figure 1L

Microglia 02
type: sao789292116
contributor: Sarah M. Maynard
comment: Alzheimer's disease patient
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

MAP5 01
type: sao2978256793
sao1939689633: Lewy Neurite 02
comment: located around ubiquitin-positive region
source: Gai WP et al. 1996. Microtubule-associated protein 5 is a component of Lewy bodies and Lewy neurites in the brainstem and forebrain regions affected in Parkinson's Disease 91:78-81.

Lewy Neurite 02
type: sao601362597
source: Gai WP et al. 1996. Microtubule-associated protein 5 is a component of Lewy bodies and Lewy neurites in the brainstem and forebrain regions affected in Parkinson's Disease 91:78-81.
sao152994059: MAP5 01
comment: located in brainstem, basal forebrain, and cortex

Hippocampal Pyramidal Neuron 01
type: sao131261273
contributor: Sarah M. Maynard
sao1623809261: Lewy Neurite 04
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2C

Lewy Neurite 04
type: sao601362597
sao152994059: Alpha-Synuclein Protein 09
contributor: Sarah M. Maynard
sao138767806: Hippocampal Pyramidal Neuron 01
comment: alpha-synuclein positive Lewy neurite in hippocampus stained with antibody PER1; human/dementia with Lewy bodies
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2C

Alpha-Synuclein Protein 09
type: sao5651809446
sao1939689633: Lewy Neurite 04
comment: stained with PER1
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2C

Alpha-Synuclein Protein 30
type: sao5651809446
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2A
sao1939689633: Lewy Neurite 11
comment: stained with PER1

Lewy Neurite 11
type: sao601362597
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2A
sao152994059: Alpha-Synuclein Protein 30
sao138767806: Substantia Nigra Dopaminergic Cell 06
comment: alpha-Synuclein positive Lewy neurite in substantia nigra stained with PER1; human/dementia with Lewy bodies

Substantia Nigra Dopaminergic Cell 06
type: sao34994437
sao1623809261: Lewy Neurite 11
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 2A
sao1863785805: false
contributor: Sarah M. Maynard

Cortical Lewy Body 01
type: sao4040591221
comment: needs source
sao1623809261: Fibril 01

Fibril 01
type: sao5051906853
sao138767806: Cortical Lewy Body 01
comment: needs source

Fibril 03
type: sao5051906853
sao138767806: Classical Lewy Body 1
comment: needs source

Classical Lewy Body 1
type: sao4749542545
comment: needs source
sao1623809261: Fibril 03

Plaque 01
type: sao9137852997
sao152994059: Amyloid 01
contributor: Sarah M. Maynard
comment: Alzheimer's disease patient
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.
sao180517057: Microglia 02

Amyloid 01
type: sao7278684532
sao1939689633: Plaque 01
comment: Alzheimer's disease patient
contributor: Sarah M. Maynard
source: Sheng JG et al. 1997. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94:1-5.

Alpha-Synuclein Fibril 02
type: sao7474011676
contributor: Sarah M. Maynard
comment: alpha-synuclein filament in cingulate cortex; human/dementia with Lewy bodies
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 4C

Corona 01
type: sao5764355747
comment: The corona has spherical accumulations of filaments (arranged in loose, radiating way)
source: Trojanowski JQ, Lee VM. 1994. Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann NY Acad Sci 747:92-109
sao1623809261: Filament 02

Filament 02
type: sao7561423738
source: Trojanowski JQ, Lee VM. 1994. Phosphorylation of neuronal cytoskeletal proteins in Alzheimer's disease and Lewy body dementias. Ann NY Acad Sci 747:92-109
sao138767806: Corona 01

sao-946766835 25
type: sao-946766835
source: Riederer B et al. 1986. MAP5: a novel brain microtubule-associated protein under strong developmental regulation. JNeurocytol 15:763-775.

Alpha-Synuclein Protein 06
type: sao5651809446
sao1939689633: Corona 02

Corona 02
type: sao5764355747
sao152994059: Alpha-Synuclein Protein 06
comment: The corona of the Lewy Body stains for alpha-synuclein.

Extracellular Space 1
type: sao1425028079
comment: dimentia with Lewy bodies
source: van der Putten H, et al. 2000. Neuropathology in Mice Expressing Human alpha-synuclein. The Journal of Neuroscience 20(16):6021-6029.

Paried Helical Filament 01
type: sao6603990120
contributor: Sarah M. Maynard
source: Spillantini MG, Crowther RA, Jakes R. Hasegawa M. 1998. Alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95(May):6469-6473. Figure 4C
comment: ulabeled paired helical filament in cingulate cortex; human/dementia with Lewy bodies